Loss of Rnf43 accelerates Kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma
A. N. Hosein, G. Dangol, T. Okumura, J. Roszik, K. Rajapakshe, M. Siemann, B. Ghosh, M. E. Monberg, P. A. Guerrero, M. Zaid, A. A. Singhi, C. L. Haymaker, H. Clevers, S. M. Woermann, L. Abou-Elkacem, A. Maitra
This study shows that loss of Rnf43 accelerates Kras-driven pancreatic cancer and alters the tumor immune microenvironment by increasing lymphocytes and immune checkpoint expression.
bioRxiv · May 29, 2021Cancer Biology