B. Ghosh

Proteomic analysis of gut in Labeo rohita reveals ECM as Key Player in host's Response to Aeromonas hydrophila Infection

This study identifies ECM proteins as key players in Labeo rohita's immune response to Aeromonas hydrophila infection through proteomic analysis of gut tissue.

Predicting Early Diabetic Kidney Disease Using a 3D Mesangial Model and Bayesian Mechano-Chemical Stratification

Decreased fucosylation impacts epithelial integrity and increases risk for COPD.

This study shows decreased fucosylation impairs epithelial integrity and increases COPD risk by affecting E-cadherin function and cell differentiation.

Proteomic discovery of chemical probes that perturb protein complexes in human cells

This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.

Blind spots on western blots: a meta-research study highlighting opportunities to improve figures and methods reporting

This paper analyzes western blot practices in top neuroscience and cell biology journals, finding widespread issues with image display and methods reporting, and provides tools to improve transparency and reproducibility.

HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPD

This study shows that HDAC6 inhibitor ACY-1083 protects lung epithelial function in COPD by reducing permeability and cytokine production under various challenges.

Tubular lysosome induction couples animal starvation to healthy aging

The paper shows that inducing tubular lysosomes through dietary restriction or mTOR inhibition links reduced food intake to lifespan extension in C. elegans.

Oncogenic KRAS Requires Complete Loss of BAP1 Function for Development of Murine Intrahepatic Cholangiocarcinoma

This study develops a mouse model showing that complete loss of BAP1 function is required for KRAS-driven intrahepatic cholangiocarcinoma.

Knockout of E-cadherin in adult mouse epithelium results in emphysema and airway disease

This study shows that loss of E-cadherin in adult mouse lung epithelium causes emphysema and airway disease, suggesting a causal role in COPD.

Loss of Rnf43 accelerates Kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma

This study shows that loss of Rnf43 accelerates Kras-driven pancreatic cancer and alters the tumor immune microenvironment by increasing lymphocytes and immune checkpoint expression.

Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity

This study identifies Praja1 as a ubiquitin ligase that degrades polyglutamine proteins and reduces their toxicity in neurodegenerative diseases.

Dynamics of the COVID -19 Related Publications

This paper analyzes the dynamics of COVID-19 related publications across PubMed, Elsevier, and ResearchGate, finding rapid growth in publication rates and geographic author distribution.

Docosahexaenoic acid (DHA), a nutritional supplement, modulates steroid insensitivity in asthma

This study shows DHA improves steroid sensitivity in asthma models and is lower in steroid-insensitive asthmatics.

Optical Coherence Tomography Reveals Self-Organizing Di-Fork Architecture of Mice Cutaneous Scars

This paper uses SS-OCT to visualize the self-organizing di-fork architecture of mouse cutaneous scars and links it to mechanobiological processes.

Quantifying Epithelial Plasticity as a Platform to Reverse Epithelial Injury

The paper quantifies epithelial plasticity changes following injury and identifies pharmacologic targets to reverse injury in COPD.

Paradoxical role of AT-rich interactive domain 1A in restraining pancreatic carcinogenesis

This study investigates the role of Arid1a in pancreatic carcinogenesis using mouse models and cell lines, finding that its loss impairs tumor growth and DNA repair but allows for later aggressive cancer development.

A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9 mediated somatic recombination

This paper develops a CRISPR-Cas9-based pipeline to generate pancreatic cancer mouse models with complex genotypes using AAV-delivered sgRNAs in adult mice.

Simvastatin mediates inhibition of exosome synthesis, localization, and secretion via multicomponent interventions.

This study shows simvastatin reduces exosome secretion by targeting cholesterol pathways in vitro and in vivo.