Author

C. L. Shirai

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Cancer Biology· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:mouse· 1

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A. Heard· 1 shared A. Khanna· 1 shared B. A. Wadugu· 1 shared C. A. Miller· 1 shared D. L. Fei· 1 shared J. Bradley· 1 shared J. Shao· 1 shared M. J. Walter· 1 shared

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2021-2021 · peak 1/yr

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1 shared paperCancer Biology

A. Heard

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1 paper

Recent·Most cited

Cancer BiologyJournal of Clinical InvestigationPeer-reviewedNov 1, 2021

U2AF1 is a haplo-essential gene required for cancer cell survival

B. A. Wadugu, A. Heard, S. N. Srivatsan…·M. J. Walter

This study shows that U2AF1 is a haplo-essential gene for cancer cell survival, as mutant cells depend on residual wild-type U2AF1 for viability and are sensitive to its reduction.

DOI 10.1172/jci141401

mouseexperimental assay

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