Author

J. Bradley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cancer Biology· 2 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:host-pathogen & immune response· 3 Research Focus:ecology & biodiversity· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. Meng· 2 shared CITIID-NIHR BioResource COVID-19 Collaboration· 2 shared J. Choi· 2 shared A. Abdullahi· 1 shared A. Barry· 1 shared A. Diarra· 1 shared A. Heard· 1 shared A. Khanna· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

B. Meng

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

SARS-CoV-2 Spike N-Terminal Domain modulates TMPRSS2-dependent viral entry and fusogenicity

B. Meng, R. Datir, J. Choi, CITIID-NIHR BioResource COVID-19 Collaboration, J. Bradley, K. G. Smith, J. H. Lee, R. K. Gupta

This study examines how mutations in the SARS-CoV-2 Spike N-Terminal Domain affect viral entry and fusogenicity, showing context-dependent modulation of spike function.

bioRxiv · May 7, 2022Microbiology

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

B. Meng, I. Ferreira, A. Abdullahi, N. Goonawardane, A. Saito, I. Kimura, D. Yamasoba, S. A. Kemp, G. Papa, S. Fatihi, S. Rathore, P. Perera Gerba, T. Ikeda, M. Toyoda, T. S. Tan, , S. Zepeda

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

bioRxiv · Dec 17, 2021Microbiology

U2AF1 is a haplo-essential gene required for cancer cell survival

B. A. Wadugu, A. Heard, S. N. Srivatsan, M. O. Alberti, M. Ndonwi, J. Bradley, J. Shao, T. Ahmed, C. L. Shirai, A. Khanna, D. L. Fei, C. A. Miller, T. A. Graubert, M. J. Walter

This study shows that U2AF1 is a haplo-essential gene for cancer cell survival, as mutant cells depend on residual wild-type U2AF1 for viability and are sensitive to its reduction.

Journal of Clinical Investigation · Nov 1, 2021Peer-reviewedCancer Biology

Heterogeneity of the Cancer Cell Line Metabolic Landscape

D. Shorthouse, J. Bradley, S. Critchlow, C. Bendtsen, B. A. Hall

This study analyzes the metabolic profiles of 173 cancer cell lines to correlate metabolic signatures with genetic mutations and drug response, revealing tissue-specific metabolic control.

bioRxiv · Aug 19, 2021Cancer Biology

Field efficacy of guppies and pyriproxyfen (Sumilarv(R) 2MR) combined with community engagement on dengue vectors in Cambodia: a randomized controlled trial

J. C. Hustedt, D. Doum, V. Keo, S. Ly, B. Sam, V. Chan, N. Alexander, J. Bradley, M. Liverani, D. B. Prasetyo, A. Rachmat, M. Shafique, S. Lopes, L. Rithea, J. Hii

This study evaluates the effectiveness of guppies and pyriproxyfen combined with community engagement in reducing dengue vector populations in Cambodia, finding significant reductions in adult female Aedes density.

bioRxiv · May 15, 2020Ecology

P. falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers

E. Meibalan, A. Barry, M. P. Gibbins, S. Awandu, L. Meerstein-Kessel, F. Achcar, S. Bopp, C. moxon, A. Diarra, S. Debe, N. Ouedraogo, I. Barry-Some, E. Badoum, T. Fagnima, K. H. W. Lanke, , T. Bousema

The paper investigates whether P. falciparum gametocytes are sequestered in skin tissue and finds no significant skin sequestration, showing peripheral blood gametocyte densities predict mosquito infection.

bioRxiv · Oct 14, 2019 · PreprintMicrobiology

Two cases of type-a Haemophilus influenzae meningitis within the same week in the same hospital are phylogenetically unrelated but recently exchanged capsule genes

Y. Terrat, L. Farnaes, J. Bradley, N. Tromas, B. J. Shapiro

This paper reports two unrelated H. influenzae meningitis cases in the same hospital, showing they were not part of a local outbreak but instead involved horizontal gene transfer of capsule genes, enabling vaccine evasion.

bioRxiv · Jun 20, 2019Microbiology

Impacts of Deep-Sea Mining on Microbial Ecosystem Services

B. N. Orcutt, J. Bradley, W. J. Brazelton, E. J. Estes, J. M. Goordial, J. A. Huber, R. M. Jones, N. Mahmoudi, J. J. Marlow, S. Murdock, M. Pachiadaki

This paper evaluates the potential impacts of deep-sea mining on microbial ecosystem services, highlighting varying levels of impact and recommending baseline assessments and protected areas.

bioRxiv · Nov 6, 2018Microbiology