Cancer BiologybioRxiv
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma
K. Mitchell, S. Shakya, S. Arora…·J. D. Lathia
This study identifies WDR5 as an essential epigenetic regulator in therapy-resistant glioblastoma cancer stem cells and shows that WDR5 inhibitors disrupt CSC maintenance and tumor growth.
DOI 10.1101/gad.349803.122