Author

K. Mitchell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Cell Biology· 1 Evolutionary Biology· 1 Microbiology· 1 Paleontology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

S. Arora· 3 shared A. Lauko· 2 shared D. J. Silver· 2 shared E. E. Mulkearns-Hubert· 2 shared J. D. Lathia· 2 shared M. Kufeld· 2 shared P. Hoellerbauer· 2 shared P. PADDISON· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCancer Biology

S. Arora

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Author profile →

11 papers

Recent·Most cited

Hormonal dynamics reveal a stimulatory role for secretoneurin in zebrafish ovulation

D. Peng, C. Lu, V. Spadacini, K. Mitchell, Y. Tan, D. Zhang, B. Levavi-Sivan, W. Hu, V. Trudeau

This study shows that secretoneurin stimulates ovulation in zebrafish by increasing gene expression in the hypothalamic-pituitary-ovarian axis and inducing ovulation in anovulatory females.

bioRxiv · Jul 3, 2024Physiology

Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury

Z. Harris, A. Korde, J. Khoury, E. Manning, G. Stanley, K. Mitchell, Y. Sun, B. Hu, H. J. Shin, J. Joerns, B. Clark, L. Placek, D. Unutmaz, H. Chun, L. Sharma, , J. Koff

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

bioRxiv · May 24, 2024Cell Biology

Skimming genomes for systematics and DNA barcodes of corals

A. M. Quattrini, L. J. McCartin, E. E. Easton, J. Horowitz, H. H. Wirshing, H. Bowers, K. Mitchell, M. Sei, C. S. McFadden, S. Herrera

This paper uses genome skimming to extract phylogenetically informative loci from coral samples, resolving phylogenetic relationships and supporting taxonomic revisions.

bioRxiv · Oct 17, 2023Evolutionary Biology

Functional genomic analysis of adult and pediatric brain tumor isolates

P. Hoellerbauer, M. Biery, S. Arora, Y. Rao, E. Girard, K. Mitchell, P. Dighe, M. Kufeld, D. Kuppers, J. Herman, E. Holland, L. Soroceanu, N. Vitanza, J. Olson, J. Pritchard, P. PADDISON

This study identifies shared and unique gene dependencies between adult and pediatric brain tumor isolates using CRISPR screens and machine learning models.

bioRxiv · Jan 5, 2023 · PreprintCancer Biology

KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

A. Mihalas, S. Arora, S. O'Connor, H. Feldman, C. E. Cucinotta, K. Mitchell, J. Bassett, D. Kim, K. Jin, P. Hoellerbauer, J. Delegard, M. Ling, W. Jenkins, M. Kufeld, P. Corrin, , P. PADDISON

This study identifies KAT5 as a regulator of G0-like states in glioblastoma, showing its role in suppressing non-dividing subpopulations and associating with worse patient outcomes.

bioRxiv · Mar 17, 2022Cancer Biology

VRK1 is a Paralog Synthetic Lethal Target in VRK2-methylated Glioblastoma

J. A. Shields, S. R. Meier, M. Bandi, M. Dam Ferdinez, J. L. Engel, E. E. Mulkearns-Hubert, N. Hajdari, K. Mitchell, W. Zhang, S.-c. Zhao, M. Zhang, R. Tjin Tham Sjin, E. Wilker, J. Lathia, J. Andersen, , N. Emmanuel

This study identifies VRK1 as a synthetic lethal target in VRK2-methylated glioblastoma by showing that VRK1 inhibition leads to tumor growth inhibition in xenograft models.

bioRxiv · Dec 30, 2021 · PreprintCancer Biology

SerpinB3 drives cancer stem cell survival in glioblastoma

A. Lauko, J. Volovetz, S. M. Turaga, D. Bayik, D. C. Watson, D. J. Silver, K. Mitchell, E. Mulkearns-Hubert, K. Desai, M. Midha, J. Hao, K. McCortney, A. Steffens, U. Naik, M. S. Ahluwalia, , J. D. Lathia

This study identifies SerpinB3 as a key driver of glioblastoma cancer stem cell survival and shows that targeting it enhances radiation therapy efficacy in pre-clinical models.

bioRxiv · Dec 21, 2021Cancer Biology

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

K. Mitchell, S. Shakya, S. Arora, S. A. Sprowls, D. J. Silver, C. M. Goins, L. Wallace, G. Roversi, R. Schafer, K. Kay, T. E. Miller, A. Lauko, A. Kashyap, J. D. Kass, E. E. Mulkearns-Hubert, , J. D. Lathia

This study identifies WDR5 as an essential epigenetic regulator in therapy-resistant glioblastoma cancer stem cells and shows that WDR5 inhibitors disrupt CSC maintenance and tumor growth.

bioRxiv · Sep 20, 2021Cancer Biology

An age-depth model and revised stratigraphy of vertebrate-bearing units in Natural Trap Cave, Wyoming

D. M. Lovelace, C. M. Redman, T. A. Minckley, B. W. Schubert, S. Mahan, J. R. Wood, J. L. McGuire, J. Laden, K. Bitterman, H. Heiniger, L. Fenderson, A. Cooper, K. Mitchell, J. A. Meachen

This study establishes a revised stratigraphy and age-depth model for Natural Trap Cave, revealing discontinuous sedimentation and reworking, and refuting a prominent snow cone's role in sediment distribution.

bioRxiv · Jul 30, 2021Paleontology

TAZ-CAMTA1 and YAP-TFE3 modulate the basal TAZ/YAP transcriptional program by recruiting the ATAC histone acetyltransferase complex

N. Merritt, K. Garcia, D. Rajendran, Z.-Y. Lin, X. Zhang, K. Mitchell, N. Borcherding, C. Fullenkamp, M. Chimenti, A.-C. Gingras, K. Harvey, M. R. Tanas

This study identifies the ATAC histone acetyltransferase complex as an oncogenic driver in EHE by showing TAZ-CAMTA1 and YAP-TFE3 recruit it to modulate transcription and chromatin structure.

bioRxiv · Sep 7, 2020Cancer Biology

PUMA: A tool for processing 16S rRNA taxonomy data for analysis and visualization

K. Mitchell, C. Dao, A. Freise, S. Mangul, J. Moberg Parker

PUMA streamlines 16S rRNA taxonomic data analysis by unifying multiple platforms and tools for efficient and reproducible microbiome research.

bioRxiv · Nov 29, 2018 · PreprintMicrobiology