S. Arora

Differential substrate specificity of ERK, JNK, and p38 MAP kinases toward Connexin 43

This study investigates the substrate specificity of ERK, JNK, and p38 MAP kinases toward Cx43CT, identifying distinct phosphorylation preferences and a novel ERK site.

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

The wheat powdery mildew resistance gene Pm4 also confers resistance to wheat blast

The paper identifies that the wheat resistance gene Pm4 confers resistance to wheat blast caused by Magnaporthe oryzae, highlighting its importance for developing resistant cultivars in affected regions.

The alphavirus TF protein plays a critical role in promoting viral propagation by altering cell-cell boundaries

This paper identifies the alphavirus TF protein's role in promoting viral propagation by altering cell-cell boundaries through downregulation of Scribble.

Liquid-liquid phase separation and aggregation of a globular folded protein SUMO1

This study shows that the globular protein SUMO1 undergoes liquid-liquid phase separation and transitions to solid aggregates under crowded conditions, challenging the assumption that only intrinsically disordered proteins can undergo LLPS.

Functional genomic analysis of adult and pediatric brain tumor isolates

This study identifies shared and unique gene dependencies between adult and pediatric brain tumor isolates using CRISPR screens and machine learning models.

Co-occurring mutations in the POLE exonuclease and non-exonuclease domains define a unique subset of highly mutagenic tumors.

The paper identifies co-occurring POLE mutations in both exonuclease and non-exonuclease domains as a novel driver of ultra-high tumor mutation burden in certain cancers.

FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation, and lethality in glioblastoma and other cancers

This study identifies FBXO42 as essential for preventing mitotic arrest and cell death in glioblastoma and other cancers by suppressing chromosome-microtubule dynamics disruption.

Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2-mutant meningiomas in mice

This study shows that YAP1-MAML2 and active YAP1 drive tumors resembling NF2-mutant meningiomas in mice through TEAD-dependent YAP activity.

Antibodies to Coagulase of Staphylococcus aureus crossreact to Efb and reveal different binding of shared Fibrinogen Binding repeats

The paper characterizes monoclonal antibodies against Staphylococcus aureus coagulase that cross-react with Efb and distinguish two functionally different Fg-binding epitopes.

KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

This study identifies KAT5 as a regulator of G0-like states in glioblastoma, showing its role in suppressing non-dividing subpopulations and associating with worse patient outcomes.

Defining cellular population dynamics at single cell resolution during prostate cancer progression

This study examines prostate cancer progression at single-cell resolution, identifying castration-resistant luminal cells and their role in treatment resistance and tumor heterogeneity.

A wheat kinase and immune receptor form the host-specificity barrier against the blast fungus

The paper identifies two wheat resistance genes that act as host-specificity barriers against the blast fungus and describes assays to incorporate these genes into wheat cultivars.

Oncogenic role of a developmentally regulated NTRK2 splice variant

The paper identifies TrkB.T1, an embryonic NTRK2 splice variant, as an oncogenic driver in multiple tumor types across species, with distinct interactors in developmental and oncogenic pathways.

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

This study identifies WDR5 as an essential epigenetic regulator in therapy-resistant glioblastoma cancer stem cells and shows that WDR5 inhibitors disrupt CSC maintenance and tumor growth.

Genome-wide analysis of in vivo CcpA binding with and without its key co-factor HPr in the major human pathogen group A Streptococcus.

This study identifies the in vivo DNA binding profile of CcpA in group A Streptococcus and shows that HPr is required for CcpA-mediated regulation and DNA binding.

Functional dissection of human mitotic proteins using CRISPR-Cas9 tiling screens

The paper uses CRISPR-Cas9 tiling screens to identify functional domains in human mitotic proteins, revealing new regions essential for cell proliferation and chromosome segregation.

Evolution of the bread wheat D-subgenome and enriching it with diversity from Aegilops tauschii

The paper sequences 242 Ae. tauschii accessions to study genetic diversity in the bread wheat D-subgenome, identifies disease resistance genes, and demonstrates their functional transfer into wheat.

Effect of earthworms in removal and fate of Antibiotic resistant bacteria (ARB) and antibiotic resistant genes (ARG) during clinical laboratory wastewater treatment by vermifiltration

This study investigates how earthworms and vermifiltration affect the removal of antibiotic resistant bacteria and genes in clinical wastewater, showing significant pathogen reduction and shifts in resistance patterns.

Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India

This study examines humoral and memory B cell responses in Indian COVID-19 recovered individuals, finding that RBD-specific IgG correlates with neutralizing antibodies and can serve as a surrogate for neutralization assays.

Design, Performance Evaluation and Investigation of the Dynamic Mechanisms of Earthworm-Microorganisms interactions for wastewater treatment through Vermifiltration technology

This study investigates earthworm-microorganism interactions in vermifiltration for wastewater treatment, finding that earthworm gut microbes dominate and that predation regulates microbial biomass and activity.

A simple and highly efficient method for multi-allelic CRISPR-Cas9 editing in primary cell cultures

This paper introduces an optimized CRISPR-Cas9 method for efficient gene knockout and genomic deletion in primary cells, achieving >90% indel formation in 3 days.

Phosphine: an eco-friendly alternative for management of wheat storage insects

This study evaluates phosphine's efficacy against wheat storage insects in different climates, finding it effective at 500-600 ppm for 7 days at specific temperatures and humidity.

Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma

The paper identifies a quiescent-like state, Neural G0, in human neural stem cells and gliomas using scRNA-seq, linking it to tumor aggressiveness and survival.

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

The paper identifies m6A mRNA methylation as a regulator of erythropoiesis by promoting the translation of key genes involved in erythroid lineage specification.

The wheat Sr22, Sr33, Sr35 and Sr45 genes confer resistance against stem rust in barley

This study assesses the functionality of cloned wheat Sr genes in barley, finding that Sr22, Sr33, Sr35, and Sr45 confer effective resistance against stem rust caused by Puccinia graminis f. sp. tritici.