Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
J. Lee, M. Nicosia, D. J. Silver, C. Li, D. Bayik, D. C. Watson, A. Lauko, S. Johnson, M. McGraw, M. Grabowski, D. Kish, A. Desai, W. Goodman, S. Cameron, H. Okada, , J. D. Lathia
This study shows male T cells are more exhausted in glioblastoma, leading to worse outcomes and better response to anti-PD1 treatment compared to females.
bioRxiv · Aug 17, 2022 · PreprintImmunology
T. Alban, M. M. Grabowski, B. Otvos, D. B. Watson, A. Zalavadia, V. Makarav, K. M. Troike, M. McGraw, A. Rabljenovic, A. Lauko, C. K. A. Neumann, G. Roversi, K. Waite, G. Cioffi, N. Patil, , J. Lathia
The paper identifies a germline SNP, rs755622, associated with increased leukocyte infiltration in glioblastoma and links it to lactotransferrin expression as a potential biomarker for immune activation.
bioRxiv · Mar 7, 2022 · PreprintCancer Biology
A. Lauko, J. Volovetz, S. M. Turaga, D. Bayik, D. C. Watson, D. J. Silver, K. Mitchell, E. Mulkearns-Hubert, K. Desai, M. Midha, J. Hao, K. McCortney, A. Steffens, U. Naik, M. S. Ahluwalia, , J. D. Lathia
This study identifies SerpinB3 as a key driver of glioblastoma cancer stem cell survival and shows that targeting it enhances radiation therapy efficacy in pre-clinical models.
bioRxiv · Dec 21, 2021Cancer Biology
D. Bayik, C. F. Bartels, K. Lovrenert, D. Watson, D. Zhang, K. Kay, A. Lauko, S. Johnson, A. Lo, M. McGraw, M. Grabowski, A. M. Mohammadi, F. Veglia, Y. Fan, M. A. Vogelbaum, , J. Lathia
The paper identifies distinct cell adhesion signatures in glioblastoma myeloid-derived suppressor cell subsets, showing that monocytic MDSCs drive tumor growth through enhanced integrin β1 expression.
bioRxiv · Sep 27, 2021Immunology
K. Mitchell, S. Shakya, S. Arora, S. A. Sprowls, D. J. Silver, C. M. Goins, L. Wallace, G. Roversi, R. Schafer, K. Kay, T. E. Miller, A. Lauko, A. Kashyap, J. D. Kass, E. E. Mulkearns-Hubert, , J. D. Lathia
This study identifies WDR5 as an essential epigenetic regulator in therapy-resistant glioblastoma cancer stem cells and shows that WDR5 inhibitors disrupt CSC maintenance and tumor growth.
bioRxiv · Sep 20, 2021Cancer Biology
D. C. Watson, D. Bayik, S. E. Williford, A. Lauko, Y. Zhou, G. Deshpande, J. Seder, J. A. Mears, F. Cheng, A. B. Hjelmeland, J. D. Lathia
The paper identifies horizontal mitochondrial transfer from astrocytes to glioblastoma cells as a mechanism that enhances tumorigenicity by improving mitochondrial function and metabolic capacity.
bioRxiv · Sep 1, 2021Cancer Biology
D. Farrell, I. Anishchanka, S. Shakeel, A. Lauko, L. A. Passmore, D. Baker, F. DiMaio
This paper uses deep learning and computational methods to determine an almost-complete atomic model of the Fanconi Anemia core complex from a low-resolution cryoEM map.
bioRxiv · May 1, 2020Biochemistry
T. Alban, D. Bayik, B. Otvos, A. Rabljenovic, L. Leng, L. Jia-shiun, G. Roversi, A. Lauko, A. Momin, A. M. Mohammadi, D. M. Peereboom, M. S. Ahluwalia, K. Matsuda, K. Yun, R. Bucala, , J. Lathia
This study identifies differential MIF receptor expression in GBM MDSC subsets and shows targeting M-MDSCs with ibudilast reduces immune suppression.
bioRxiv · Dec 19, 2019Immunology
D. Bayik, A. Lauko, G. A. Roversi, E. Serbinowski, L.-A. Acevedo-Moreno, C. Lanigan, M. Orujov, A. Lo, T. Alban, D. J. Silver, J. M. Brown, D. S. Allende, F. N. Aucejo, J. D. Lathia
The paper identifies a distinct myeloid-derived suppressor cell (MDSC) signature in cholangiocarcinoma (CCA) compared to other hepatobiliary cancers, linking MDSC levels to disease outcomes and potential therapeutic targets.
bioRxiv · Dec 11, 2019 · PreprintPathology