Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
J. Belk, W. Yao, N. Ly, K. Freitas, Y.-T. Chen, Q. Shi, A. Valencia, E. Shifrut, N. Kale, K. Yost, C. Duffy, M. Hwee, Z. Miao, A. Ashworth, C. Mackall, , A. Satpathy
This study identifies chromatin remodeling factors that limit T cell persistence using CRISPR screens and shows their impact on anti-tumor immunity.
bioRxiv · Apr 20, 2022Immunology