Y.-T. Chen

Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2

This study shows hydrogen sulfide destabilizes PKM2 tetramer through sulfhydration at cysteine 326, rewiring glucose metabolism and inhibiting tumor growth.

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.

Novel adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

This study identifies two macrophage states induced by chronic hypoxia that enhance efferocytosis through metabolic and transcriptional adaptations.

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

This study identifies chromatin remodeling factors that limit T cell persistence using CRISPR screens and shows their impact on anti-tumor immunity.

Immune function of the serosa in hemimetabolous insect eggs

The paper investigates immune function in the serosa of hemimetabolous insect eggs, finding immune competence is ancestral to all insects.

Chemoproteomic profiling reveals cellular targets of nitro-fatty acids

This study identifies 184 nitro-alkylated proteins in human macrophages using a clickable nitro-fatty acid probe, revealing novel targets and pathways involved in nitro-fatty acid biology.

Chasing the metabolism of novel syntrophic acetate-oxidizing bacteria in thermophilic methanogenic chemostats

This study identifies and characterizes novel syntrophic acetate-oxidizing bacteria in thermophilic methanogenic chemostats, revealing their metabolic pathways and interactions with methanogenic partners.

miRNA-34c suppresses osteosarcoma progression in vivo by targeting Notch and E2F

This study shows miR-34c suppresses osteosarcoma progression by targeting Notch and E2F pathways, improving survival in mouse models and correlating with better patient outcomes.

RHAMMB-mediated bifunctional nanotherapy targeting Bcl-xL and mitochondria for pancreatic neuroendocrine tumor treatment

This paper develops a RHAMMB-targeting nanoparticle delivering siBcl-xL and KLA peptide to treat PNETs, showing synergistic tumor reduction in mice.

High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate theprogression of pancreatic cancer

Factors that affect protein abundance of the bZIP transcription factor ABRE-BINDING FACTOR 2 (ABF2), a positive regulator of abscisic acid signaling

This study investigates the proteolytic regulation of ABF2, a bZIP transcription factor, and compares its degradation dynamics with ABI5, revealing differences in stability and regulatory mechanisms between vegetative ABFs and ABI5.

Striking parallels between dorsoventral patterning in Drosophila and Gryllus reveal a complex evolutionary history behind a model gene regulatory network

The paper compares dorsoventral patterning in Drosophila and Gryllus, finding similarities in Toll signaling roles and suggesting convergent evolution or an ancient insect regulatory network.

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

A cocktail of neutralizing antibodies targeting SARS-CoV-2 spike protein's NTD and RBD, when used as immunogens in rabbits, elicited strong protective immune responses.

HDGF supports anti-apoptosis and pro-fibrosis in pancreatic stellate cells of pancreatic cancer

This study identifies the TGF-β1-activated CEBPD/HIF-1/HDGF axis in pancreatic stellate cells, showing HDGF promotes anti-apoptosis and pro-fibrosis, contributing to pancreatic cancer progression.

AhRLK1, a CLAVATA1-like leucine-rich repeat receptor-like kinase of peanut, confers increased resistance to bacterial wilt in tobacco

This study identifies AhRLK1, a peanut receptor-like kinase, which enhances resistance to Ralstonia solanacearum in tobacco through hypersensitive response and hormone signaling.