ImmunologybioRxiv
Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages
S. R. Bryden, M. Pingen, D. R. Lefteri…·C. McKimmie
The paper shows that activating innate immune responses at the mosquito bite site, specifically targeting skin-resident macrophages, can inhibit systemic arbovirus dissemination and improve clinical outcomes.
DOI 10.1126/scitranslmed.aax2421