Author

A. Tuplin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Harris· 4 shared K. Sun· 2 shared A. A. Khromykh· 1 shared A. M. G. Colmant· 1 shared A. Merits· 1 shared A. Slonchak· 1 shared B. Pullinger· 1 shared C. J. McCormick· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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4 shared papersMicrobiology

M. Harris

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Author profile →

6 papers

Recent·Most cited

A structural and functional analysis of opal stop codon translational readthrough during Chikungunya Virus replication

R. Li, K. Sun, A. Tuplin, M. Harris

This study investigates the role of opal stop codon translational readthrough in CHIKV replication by replacing stop codons and analyzing structural and functional effects.

bioRxiv · Jul 24, 2023Microbiology

A novel interaction between the 5' untranslated region of the Chikungunya virus genome and Musashi RNA binding protein is essential for efficient virus genome replication.

K. Sun, F. Appadoo, Y. Liu, M. Muller, C. Macfarlane, M. Harris, A. Tuplin

This study identifies Musashi RNA binding proteins as essential for Chikungunya virus genome replication and suggests a potential therapeutic target.

bioRxiv · Mar 29, 2023Microbiology

Positive strand RNA viruses differ in the constraints they place on the folding of their negative strand

M. R. Herod, J. Ward, A. Tuplin, M. Harris, N. J. Stonehouse, C. J. McCormick

The paper investigates differences in conformational constraints on negative strand RNA folding among positive strand RNA viruses, finding significant variation in ribozyme activity and duplex formation.

bioRxiv · Feb 1, 2022Microbiology

Structural analysis of 3'UTRs in insect flaviviruses reveals novel determinant of sfRNA biogenesis and provides new insights into flavivirus evolution

A. Slonchak, R. Parry, B. Pullinger, J. D. J. Sng, X. Wang, T. F. Buck, F. J. Torres, J. J. Harrison, A. M. G. Colmant, J. Hobson-Peters, R. A. Hall, A. Tuplin, A. A. Khromykh

This study analyzes 3'UTRs of insect flaviviruses to identify novel xrRNAs involved in sfRNA biogenesis and provides insights into flavivirus evolution.

bioRxiv · Jun 23, 2021Microbiology

Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages

S. R. Bryden, M. Pingen, D. R. Lefteri, J. Major, L. Delang, S. Jacobs, R. Abdelnabi, J. Neyts, J. Miltenburg, H. Khalid, A. Tuplin, A. Merits, E. Pondeville, J. Edgar, G. J. Graham, , C. McKimmie

The paper shows that activating innate immune responses at the mosquito bite site, specifically targeting skin-resident macrophages, can inhibit systemic arbovirus dissemination and improve clinical outcomes.

bioRxiv · Mar 4, 2019Immunology

Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription

Y. Gao, N. Goonawardane, A. Tuplin, M. Harris

This paper identifies multiple roles of the nsP3 AUD domain in CHIKV genome replication and transcription, showing its involvement in RNA replication and virus assembly.

bioRxiv · Jul 25, 2018Microbiology