M. Pingen

Lung structural cell dynamics are altered by influenza virus infection experience leading to rapid immune protection following viral re-challenge

The paper shows that lung structural cells retain an inflammatory imprint after influenza infection, enabling faster viral control upon re-challenge.

Triphasic production of IFNγ by innate and adaptive lymphocytes following influenza A virus infection

This study identifies a triphasic production of IFNγ by different immune cell types during and after influenza A virus infection, highlighting memory-like phenotypes in some cells.

Mosquito saliva sialokinin-dependent enhancement of arbovirus infection through endothelial barrier leakage

This study identifies sialokinin in Aedes mosquito saliva as a factor that enhances arbovirus infection by reducing endothelial barrier integrity, suggesting it as a therapeutic target.

A novel antiviral formulation inhibits a range of enveloped viruses.

This study evaluates a novel antiviral formulation, ViroSAL, which inhibits multiple enveloped viruses in vitro and in vivo by disrupting viral envelopes.

Chemokine receptors ACKR2 and CCR1 coordinate macrophage dynamics and mammary gland development

The paper shows ACKR2 and CCR1 regulate macrophage dynamics and mammary gland development by controlling CCL7 levels and macrophage movement.

A novel methodology for defining stromal expression of atypical chemokine receptors in vivo

This paper introduces a novel method to detect atypical chemokine receptor expression on stromal cells using Alexa-Fluor labelled chemokine ligands, demonstrating ACKR2 expression on blood endothelial cells in the lung.

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

The paper identifies M2-N31 inhibitors that show synergistic antiviral effects when combined with existing drugs, offering a strategy to combat rimantadine-resistant influenza.

Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages

The paper shows that activating innate immune responses at the mosquito bite site, specifically targeting skin-resident macrophages, can inhibit systemic arbovirus dissemination and improve clinical outcomes.