Author

A. Merits

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:Arabidopsis· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

R. Fragkoudis· 3 shared B. Atkinson· 2 shared C. M. Reitmayer· 2 shared E. Levitt· 2 shared E. Pondeville· 2 shared E. Zusinaite· 2 shared L. Alphey· 2 shared M. Pingen· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

R. Fragkoudis

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A Zika virus-responsive sensor-effector system in Aedes aegypti

S. Basu, C. M. Reitmayer, S. Lumley, B. Atkinson, M. L. Schade-Weskott, S. Rooney, W. Larner, E. E. Montiel, R. Gutierrez-Lopez, E. Levitt, H. M. Munyanduki, A. M. E. Elrefaey, A. T. Clarke, S. Koit, E. Zusinaite, , L. Alphey

This paper describes a genetic system in Aedes aegypti mosquitoes that selectively eliminates ZIKV-infected individuals to reduce vectorial capacity.

bioRxiv · Feb 6, 2023 · PreprintBioengineering

Fake it to break it: mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito Aedes aegypti

C. M. Reitmayer, E. Levitt, S. Basu, B. Atkinson, R. Fragkoudis, A. Merits, S. Lumley, W. Larner, A. V. Diaz, S. Rooney, C. J. E. Thomas, K. von Wyschetzki, K. Rausalu, L. Alphey

The paper demonstrates that mimicking superinfection exclusion in mosquitoes reduces alphavirus replication and transmission.

bioRxiv · Sep 20, 2022 · PreprintMicrobiology

Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

W. Kamel, V. Ruscica, A. Embarc-Buh, Z. R. de Laurent, M. Garcia-Moreno, Y. Demyanenko, M. Madhusudhan, L. Iselin, A. Järvelin, M. Hannan, E. Kitano, S. Moore, A. Merits, I. Davis, S. Mohammed, A. Castello

This study identifies nuclear RNA-binding proteins that are translocated to the cytoplasm during alphavirus infection and exhibit antiviral activity.

bioRxiv · Oct 6, 2021Microbiology

Mosquito saliva sialokinin-dependent enhancement of arbovirus infection through endothelial barrier leakage

D. Lefteri, S. Bryden, M. Pingen, S. Terry, E. Beswick, G. Georgiev, M. Van Der Laan, V. Mastrullo, P. Campagnolo, R. M. Waterhouse, M. Varjak, A. Merits, R. Fragkoudis, S. Griffin, E. Pondeville, C. S. McKimmie

This study identifies sialokinin in Aedes mosquito saliva as a factor that enhances arbovirus infection by reducing endothelial barrier integrity, suggesting it as a therapeutic target.

bioRxiv · Feb 19, 2021Microbiology

In vitro evolution of Remdesivir resistance reveals genome plasticity of SARS-CoV-2

A. M. Szemiel, A. Merits, R. J. Orton, O. MacLean, A. Wickenhagen, G. Lieber, R. M. Pinto, M. L. Turnbull, S. Wang, D. Mair, A. da Silva Filipe, B. J. Willett, S. J. Wilson, A. H. Patel, E. C. Thomson, , M. E. Stewart

This study shows that in vitro evolution of SARS-CoV-2 under remdesivir selects for resistant mutations, but these mutations do not spread widely in global variants.

bioRxiv · Feb 1, 2021Microbiology

Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivo

A. Ianevski, R. Yao, E. Zusinaite, L. S. Lello, S. Wang, E. Jo, J. Yang, E. Ravlo, W. Wang, H. Lysvand, K. Loseth, V. Oksenych, T. Tenson, M. P. Windisch, M. Poranen, , D. E. Kainov

This study shows that IFNa-based combinations effectively inhibit SARS-CoV-2 infection in vitro and in vivo, with synergistic effects against other viruses.

bioRxiv · Jan 5, 2021 · PreprintMicrobiology

Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages

S. R. Bryden, M. Pingen, D. R. Lefteri, J. Major, L. Delang, S. Jacobs, R. Abdelnabi, J. Neyts, J. Miltenburg, H. Khalid, A. Tuplin, A. Merits, E. Pondeville, J. Edgar, G. J. Graham, , C. McKimmie

The paper shows that activating innate immune responses at the mosquito bite site, specifically targeting skin-resident macrophages, can inhibit systemic arbovirus dissemination and improve clinical outcomes.

bioRxiv · Mar 4, 2019Immunology

Persistent Chikungunya Virus Replication in Human Cells is Associated with Presence of Stable Cytoplasmic Granules Containing Non-structural Protein 3

R. Remenyi, Y. Gao, R. E. Hughes, A. Curd, C. Zothner, M. Peckham, A. Merits, M. Harris

This paper identifies stable cytoplasmic granules containing nsP3 in persistently infected CHIKV cells, showing their long-term persistence and implications for chronic disease.

bioRxiv · Feb 14, 2018Microbiology