Author

C. Nosala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

S. C. Dawson· 5 shared K. D. Hagen· 4 shared A. Aebischer· 2 shared A. Mueller· 2 shared C. Klotz· 2 shared J. K. Pham· 2 shared K. Jones· 2 shared K. Nguyen· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersMicrobiology

S. C. Dawson

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6 papers

Recent·Most cited

Dynamic ventral disc contraction is necessary for Giardia attachment and host pathology

C. Nosala, K. D. Hagen, S. L. Guest, N. A. Hilton, A. Mueller, M. Laue, C. Klotz, A. Aebischer, S. C. Dawson

This study shows Giardia's ventral disc contracts during attachment, causing host cell damage, and identifies three contraction types that reduce disc size.

bioRxiv · Jul 4, 2023 · PreprintMicrobiology

The domed architecture of Giardias ventral disc is necessary for attachment and host pathogenesis

K. D. Hagen, C. Nosala, N. Hilton, A. Mueller, D. Holthaus, M. Laue, C. Klotz, A. Aebischer, S. C. Dawson

This study shows that Giardia's ventral disc, shaped by MBP, is essential for attachment and causing host epithelial barrier damage.

bioRxiv · Jul 2, 2023 · PreprintMicrobiology

The hyperstability and composition of Giardias ventral disc highlights the remarkable versatility of microtubule organelles

C. Nosala, K.D. Hagen, T.M. Chase, K. Jones, R. Loudermilk, K. Nguyen, S.C. Dawson

The paper identifies 54 new disc-associated proteins in Giardia's ventral disc and shows its hyperstable microtubule array is stabilized by novel and conserved proteins.

bioRxiv · Oct 30, 2018 · PreprintMicrobiology

Robust and stable transcriptional repression in Giardia using CRISPRi

S. G. McInally, K. D. Hagen, C. Nosala, J. Williams, K. Nguyen, J. Booker, K. Jones, S. C. Dawson

This study develops CRISPRi for stable transcriptional repression in Giardia, demonstrating efficient gene knockdown and phenotypic effects.

bioRxiv · Sep 28, 2018Microbiology

Giardia colonizes and encysts in high density foci in the murine small intestine

N. Barash, C. Nosala, J. K. Pham, S. G. McInally, S. Gourguechon, B. McCarthy-Sinclair, S. C. Dawson

This paper uses bioluminescent imaging to study Giardia infection dynamics in mice, revealing non-uniform colonization and encystation patterns in high-density gut foci.

mSphere · Jun 28, 2017Peer-reviewedMicrobiology

Transcriptomic profiling of high-density Giardia foci encysting in the murine proximal intestine

J. K. Pham, C. Nosala, E. Y. Scott, K. F. Nguyen, K. D. Hagen, H. N. Starcevich, S. C. Dawson

This study compares in vivo gene expression of Giardia in high-density gut foci with axenic culture, finding higher expression of encystation-related genes and identifying novel cyst-specific proteins.

Frontiers in Cellular and Infection Microbiology · May 31, 2017Peer-reviewedMicrobiology