M. Laue

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites.

The paper screens the MMV Pathogen Box to identify compounds active against Toxoplasma gondii bradyzoites and finds the mitochondrial bc1-complex as a drug target.

The formation of Chlamydia-containing spheres, a novel non-lytic egress pathway of the zoonotic pathogen Chlamydia psittaci

Dynamic ventral disc contraction is necessary for Giardia attachment and host pathology

This study shows Giardia's ventral disc contracts during attachment, causing host cell damage, and identifies three contraction types that reduce disc size.

The domed architecture of Giardias ventral disc is necessary for attachment and host pathogenesis

This study shows that Giardia's ventral disc, shaped by MBP, is essential for attachment and causing host epithelial barrier damage.

First virological and pathological study of Göttingen Minipigs with Dippity Pig Syndrome (DPS)

This study investigates the virological and pathological features of Dippity Pig Syndrome (DPS) in Göttingen Minipigs, identifying some viral infections and suggesting a multifactorial cause.

Morphometry of SARS-CoV and SARS-CoV-2 particles in ultrathin plastic sections of infected Vero cell cultures.

The paper compares the morphology and size distribution of SARS-CoV and SARS-CoV-2 particles in Vero cell cultures using electron microscopy, finding similar particle sizes but a higher spike count in SARS-CoV.

Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity

This study shows that type I interferons can enhance NK cell killing of HIV-1-reactivating T-cells despite HDACi-induced immune dysregulation, suggesting a potential strategy to improve shock-and-kill approaches.