A. Seth

Automated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications

This study presents an automated single-cell proteomics workflow that identifies over 4,000 proteins per cell and detects key regulatory proteins in LPS-perturbed THP-1 cells.

Empowering human-like walking with a bio-inspired gait controller for an under-actuated torque- driven human model

This paper proposes a bio-inspired gait controller for a torque-driven human model to achieve stable walking with minimal energy expenditure and robustness to disturbances.

Genome editing in the mouse brain with minimally immunogenic Cas9 RNPs

This study demonstrates that minimally immunogenic Cas9 RNPs delivered via convection enhanced delivery can edit mouse striatal neurons with reduced immune responses compared to AAV-delivered Cas9.

Minimization of metabolic cost of transport predicts changes in gait mechanics over a range of ankle-foot orthosis stiffnesses in individuals with bilateral plantar flexor weakness

This study uses simulations to show that minimizing metabolic cost of transport predicts gait adaptations to varying ankle-foot orthosis stiffness in individuals with plantar flexor weakness.

Single cell preparations of Mycobacterium tuberculosis damage the mycobacterial envelope and disrupt macrophage interactions

This study shows that common methods to prepare Mycobacterium tuberculosis for experiments damage the bacterial envelope, alter macrophage responses, and affect bacterial survival.

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

The paper identifies two novel inhibitors of the serotonin transporter that selectively target the inward-open conformation, showing improved potency and reduced off-target effects compared to existing drugs.

Distinct glycerophospholipids potentiate Gsα-activated adenylyl cyclase activity

The paper identifies specific glycerophospholipids that enhance Gsα-activated adenylyl cyclase activity, suggesting an intracellular regulatory role.

OpenSense: An open-source toolbox for Inertial-Measurement-Unit-based measurement of lower extremity kinematics over long durations

OpenSense estimates lower extremity joint kinematics from IMUs with accuracy comparable to optical motion capture and minimal drift over 10 minutes.

An automated workflow for multiplexed single-cell proteomics sample preparation at unprecedented sensitivity.

This paper introduces an automated workflow for single-cell proteomics with high sensitivity and throughput, demonstrating its ability to distinguish cell types and reveal biological insights.

Leishmania major formins are cytosolic actin bundler play an important role in cell physiology

This study identifies and characterizes two formins in Leishmania major, showing they bind and bundle actin, and are essential for parasite growth and morphology.

Muscle coordination retraining inspired by musculoskeletal simulations: a study on reducing knee loading

This study uses musculoskeletal simulations to retrain muscle coordination via biofeedback, reducing knee loading in healthy individuals during walking.

Gsalpha stimulation of mammalian adenylate cyclases regulated by their hexahelical membrane anchors

The paper shows that mammalian adenylate cyclase membrane anchors act as receptors, transducing extracellular signals to regulate enzyme activity, with serum factors inhibiting AC stimulation.

Domain-general enhancements of metacognitive ability through adaptive training

This study shows that adaptive training improves metacognitive calibration across different tasks and stimuli, enhancing introspection about self-performance.