ImmunologybioRxiv
Ageing compromises mouse thymus function and remodels epithelial cell differentiation
C. P. Ponting, J. Baran-Gale, M. D. Morgan…·G. A. Holländer
This study investigates how ageing affects mouse thymus function, revealing that progenitor cell differentiation is disrupted, leading to impaired T cell selection and self-antigen representation.