Voltage-Gated Potassium Channel Kv1.3 as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma
W. Li, G. Wilson, M. Bachmann, J. Wang, A. Mattarei, C. Paradisi, M. Edwards, I. Szabo, E. Gulbins, S. Ahmad, S. Patel
This study shows Kv1.3 is highly expressed in human PDAC and novel Kv1.3 inhibitors combined with chemotherapy significantly reduce tumor growth in mouse models.
bioRxiv · Feb 3, 2021 · PreprintCancer Biology