Structural basis of resistance to lincosamide, streptogramin A, and pleuromutilin antibiotics by ABCF ATPases in Gram-positive pathogens
C. Crowe-McAuliffe, V. Murina, K. J. Turnbull, M. Kasari, M. Mohamad, C. Polte, H. Takada, K. Vaitkevicius, J. Johansson, Z. Ignatova, G. C. Atkinson, A. C. O'Neill, V. Hauryliuk, D. N. Wilson
The paper determines the structures of ARE ABCF-ribosome complexes from three Gram-positive bacteria and proposes a model for antibiotic resistance mechanisms.
bioRxiv · Nov 24, 2020Microbiology