Structural basis for PoxtA-mediated resistance to Phenicol and Oxazolidinone antibiotics
C. Crowe-McAuliffe, V. Murina, M. Kasari, H. Takada, K. J. Turnbull, Y. S. Polikanov, A. Sundsfjord, K. Hegstad, G. C. Atkinson, D. N. Wilson, V. Hauryliuk
This paper presents cryo-EM structures of PoxtA bound to the ribosome, revealing its mechanism of antibiotic resistance by perturbing tRNA and altering nascent chain conformation.
bioRxiv · Jun 18, 2021Microbiology