C. R. Bartman

One-carbon unit supplementation fuels tumor-infiltrating T cells and augments checkpoint blockade

This study shows that supplementing one-carbon units enhances anti-PD-1 checkpoint blockade by supporting purine synthesis in tumor-infiltrating T cells, leading to increased durable tumor regression.

Slow TCA flux implies low ATP production in tumors

This study quantifies TCA flux in tumors and healthy tissues, finding suppressed ATP production in tumors despite increased glycolysis.