Author

V. Bhatt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Y. Guo· 4 shared Z. S. Hu· 4 shared J. D. Rabinowitz· 3 shared E. White· 2 shared T. Lan· 2 shared W. Wang· 2 shared X. Luo· 2 shared X. Su· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersCancer Biology

J. Y. Guo

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Author profile →

4 papers

Recent·Most cited

RESPIRATION DEFECTS LIMIT SERINE SYNTHESIS REQUIRED FOR LUNG CANCER GROWTH AND SURVIVAL

E. Cararo Lopes, F. Shi, A. Sawant, M. Ibrahim, M. Gomez-Jenkins, Z. S. Hu, P. Manchiraju, V. Bhatt, W. Wang, C. S. Hinrichs, D. C. Wallace, X. Su, J. D. Rabinowitz, C. Chan, J. Y. Guo, , E. White

This study shows that mitochondrial DNA mutations in NSCLC cause respiration defects, leading to glucose dependency, reduced serine synthesis, and increased cancer survival.

bioRxiv · May 28, 2024 · PreprintCancer Biology

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

T. Lan, S. Arastu, S. Wang, J. Lam, W. Wang, V. Bhatt, E. C. Lopes, Z. S. Hu, M. Sun, X. Luo, J. M. Ghergurovich, C. Li, X. Su, J. D. Rabinowitz, E. White, J. Y. Guo

This study shows that G6PD is critical for redox balance and biosynthesis in LKB1-deficient KRAS-driven lung cancer, but not in KP tumors, and identifies potential therapeutic strategies.

bioRxiv · Oct 6, 2023 · PreprintCancer Biology

Slow TCA flux implies low ATP production in tumors

C. R. Bartman, Y. Shen, W. D. Lee, T. TeSlaa, C. S. R. Jankowski, L. Wang, L. Yang, A. Roichman, V. Bhatt, T. Lan, Z. S. Hu, X. Xing, W. Lu, J. Y. Guo, J. D. Rabinowitz

This study quantifies TCA flux in tumors and healthy tissues, finding suppressed ATP production in tumors despite increased glycolysis.

bioRxiv · Oct 4, 2021 · PreprintCancer Biology

Autophagy Compensates for Lkb1 Loss to Maintain Adult Mice Homeostasis and Survival

J. Y. Guo, K. Khayati, V. Bhatt, Z. S. Hu, S. Fahumy, X. Luo

This study shows autophagy compensates for Lkb1 loss in adult mice, improving survival and mitigating metabolic and intestinal defects.

bioRxiv · Aug 26, 2020Cell Biology