Author

C. Ritchie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

L. Li· 6 shared A. F. Cordova· 3 shared G. T. Hess· 2 shared M. C. Bassik· 2 shared V. Böhnert· 2 shared B. F. Cravatt· 1 shared E. Njomen· 1 shared J. A. Carozza· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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6 shared papersBiochemistry

L. Li

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6 papers

Recent·Most cited

Human STING oligomer function is governed by palmitoylation of an evolutionarily conserved cysteine

R. J. M. Chan, X. Cao, S. L. Ergun, E. Njomen, S. R. Lynch, C. Ritchie, B. F. Cravatt, L. Li

This paper identifies palmitoylation at C64 as critical for preventing unproductive STING oligomerization and shows a peptide inhibitor targeting the oligomerization interface.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

STING activation of IRF3 is tuned by PELI2 to suppress basal activation and reinforce the anti-viral response

C. Ritchie, L. Li

This study identifies PELI2 as a regulator of the STING pathway that suppresses basal IRF3 signaling and enhances NF-κB signaling to modulate anti-viral responses and prevent interferonopathies.

bioRxiv · Apr 15, 2023 · PreprintBiochemistry

Human SLC46A2 is the dominant cGAMP importer in extracellular cGAMP-sensing macrophages and monocytes

A. F. Cordova, C. Ritchie, V. Böhnert, L. Li

The paper identifies SLC46A2 as the primary cGAMP importer in human monocytes and macrophages, revealing its role in cGAMP sensing and potential therapeutic applications.

bioRxiv · Apr 15, 2020Cancer Biology

The LRRC8A:C Heteromeric Channel Is a cGAMP Transporter and the Dominant cGAMP Importer in Human Vasculature Cells

L. J. Lahey, X. Wen, R. E. Mardjuki, V. Böhnert, G. T. Hess, C. Ritchie, J. A. Carozza, M. Maduke, M. C. Bassik, L. Li

The paper identifies LRRC8A:C as a cGAMP transporter in human vasculature cells and shows it mediates cGAMP import/export and is the dominant importer in these cells.

bioRxiv · Feb 13, 2020 · PreprintBiochemistry

In response to Luteijn et al.: Concerns regarding cGAMP uptake assay and evidence that SLC19A1 is not the major cGAMP importer in human PBMCs

C. Ritchie, A. F. Cordova, L. Li

bioRxiv · Oct 18, 2019 · PreprintBiochemistry

SLC19A1 is an importer of the immunotransmitter cGAMP

A. F. Cordova, C. Ritchie, G. T. Hess, M. C. Bassik, L. Li

The paper identifies SLC19A1 as the importer of cGAMP and other CDNs, revealing its role in activating the STING pathway and informing CDN-based cancer therapy development.

bioRxiv · Feb 3, 2019Biochemistry