X. Cao

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

A phosphorylation-controlled switch confers cell cycle-dependent protein relocalization

The paper develops a system for mitosis-specific protein recruitment to the plasma membrane using a phosphorylation-controlled switch, without exogenous triggers.

Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

This study analyzes single-cell transcriptomes of gastric cancer with and without H. pylori infection to identify immune and angiogenic signatures predictive of immunotherapy response.

MoLst8 regulates autophagy and lipid homeostasis in Magnaporthe oryzae

This study investigates the role of MoLst8 in autophagy and lipid homeostasis in Magnaporthe oryzae, showing its positive regulation of TORC1 and disruption of lipid metabolism in a knockout mutant.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system

This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

Spherical Echo-Planar Time-resolved Imaging (sEPTI) for rapid 3D quantitative T2* and Susceptibility imaging

This paper introduces sEPTI, a 3D imaging technique for rapid whole-brain T2* and susceptibility mapping, achieving faster imaging and improved quality compared to existing methods.

Large-scale multi-omics analyses identified root-microbiome associations underlying plant nitrogen nutrition

The paper identifies root-microbiome associations affecting plant nitrogen nutrition through multi-omics analyses of 1,341 rapeseed samples.

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

Comparison and Evaluation of Neutralization of Clinically Frequently Used Antimicrobial Agents Using Three Different Culture Media in Simulated Blood Cultures

This study evaluates three blood culture media for antimicrobial neutralization, finding BACT/ALERT media outperformed others in recovery rates, while Thermo media had the lowest performance.

Intraspecies interactions of Streptococcus mutans impact biofilm architecture and virulence determinants in childhood dental caries

This study investigates how intraspecies interactions between Streptococcus mutans strains affect biofilm properties and virulence in early childhood dental caries using in vitro and in vivo models.

Gain of chromosome region 1q31.3 in human iPSCs confers growth advantage and alters contraction in derivative cardiomyocytes

The paper shows that a gain of chromosome 1q31.3 in human iPSCs leads to increased TNNT2 expression and altered contraction in derived cardiomyocytes.

E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation

This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.

AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection

This study shows LGG metabolites activate ILC3 cells via AhR to produce IL-22, which prevents PEDV infection in piglets by enhancing intestinal cell proliferation and STAT3 signaling.

Single phage proteins sequester TIR- and cGAS-generated signaling molecules

This study identifies Tad1 and Tad2 as phage proteins that sequester cyclic nucleotides produced by TIR and cGAS systems to inhibit anti-phage immunity.

Senescence of endplate osteoclasts induces sensory innervation and spinal pain

This study identifies senescent osteoclasts in spinal models as contributors to pain through nerve growth and vessel formation, showing their removal reduces hypersensitivity.

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

The paper identifies sphingolipids as regulators of synphilin-1 inclusion body maturation and detoxification in yeast and mammalian cells.

Human STING oligomer function is governed by palmitoylation of an evolutionarily conserved cysteine

This paper identifies palmitoylation at C64 as critical for preventing unproductive STING oligomerization and shows a peptide inhibitor targeting the oligomerization interface.

Large-scale lensless microscopy with fast acquisition and region-wise focusing

This paper develops a fast acquisition and region-wise focusing strategy for lensless microscopy, achieving high-resolution imaging of biological samples with reduced acquisition and reconstruction times.

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota

This study shows ASB3 worsens inflammatory bowel disease by destabilizing TRAF6 and altering gut microbiota, suggesting ASB3 inhibition could be a therapeutic strategy.

The TOR signaling pathway regulates vegetative development, aflatoxin biosynthesis, and pathogenicity in Aspergillus flavus

This study identifies and characterizes nine genes in the TOR signaling pathway of A. flavus, revealing their roles in growth, aflatoxin biosynthesis, and pathogenicity.

Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis.

The paper identifies myeloid cell influx and epithelial cell perturbations in ulcerative colitis, linking them to disease severity and anti-TNF therapy non-response.

Zoledronic acid improves bone quality and muscle function in a high bone turnover state

This study shows zoledronic acid improves bone quality and muscle function in a mouse model of metabolic bone disease by reducing TGFβ release from bone.

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides

This paper identifies Acb2 as a phage-encoded protein that sequesters multiple cyclic dinucleotides and trinucleotides, inhibiting CBASS immunity.