Author

M. Maduke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. C. Cheng· 2 shared A. K. Koster· 1 shared A. Koehl· 1 shared A. Krishnamoorti· 1 shared A. S. Powers· 1 shared C. Ritchie· 1 shared E. Tajkhorshid· 1 shared G. Pintilie· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

R. C. Cheng

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5 papers

Recent·Most cited

CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism

M. Xu, T. Neelands, A. S. Powers, Y. Liu, S. D. Miller, G. Pintilie, J. Du Bois, R. O. Dror, W. Chiu, M. Maduke

The paper reports cryoEM structures of human CLC-2 chloride channels, revealing a ball-and-chain gating mechanism involving an N-terminal hairpin peptide.

bioRxiv · Aug 13, 2023Biophysics

Single-molecule FRET monitors CLC transporter conformation and subunit independence

R. C. Cheng, A. Krishnamoorti, V. Berka, R. J. Durham, V. Jayaraman, M. Maduke

This study uses smFRET to monitor CLC-ec1 conformational changes and shows subunit independence in transport.

bioRxiv · Sep 7, 2020 · PreprintBiophysics

The LRRC8A:C Heteromeric Channel Is a cGAMP Transporter and the Dominant cGAMP Importer in Human Vasculature Cells

L. J. Lahey, X. Wen, R. E. Mardjuki, V. Böhnert, G. T. Hess, C. Ritchie, J. A. Carozza, M. Maduke, M. C. Bassik, L. Li

The paper identifies LRRC8A:C as a cGAMP transporter in human vasculature cells and shows it mediates cGAMP import/export and is the dominant importer in these cells.

bioRxiv · Feb 13, 2020 · PreprintBiochemistry

Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating

K. A. McKiernan, A. K. Koster, M. Maduke, V. S. Pande

This paper uses molecular dynamics simulations to model CLC-2 ion channel conformational changes, revealing how GLUex protonation affects gate opening and selectivity-filter gating.

bioRxiv · Dec 1, 2019Biophysics

Structural characterization of an intermediate reveals a unified mechanism for the CLC Cl-/H+ transport cycle

T. S. Chavan, R. C. Cheng, T. Jiang, I. I. Mathews, R. A. Stein, A. Koehl, H. S. Mchaourab, E. Tajkhorshid, M. Maduke

The paper presents a 2.6 Å structure of a CLC mutant, revealing a global conformational change that supports a unified transport mechanism for CLC proteins.

bioRxiv · Nov 27, 2019Biophysics