Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress
K. J. Morgan, K. Doggett, F.-S. Geng, L. Whitehead, K. A. Smith, B. M. Hogan, C. Simons, G. J. Baillie, R. Molania, A. T. Papenfuss, T. E. Hall, E. A. Ober, D. Y. R. Stainier, Z. Gong, J. K. Heath
The paper shows that reducing Elys function in a zebrafish model of Kras-driven liver cancer reduces tumour burden by inducing DNA damage and cell death.
bioRxiv · Aug 25, 2021Cancer Biology