Z. Gong

The paper introduces AggreBots, a platform for creating designer motility patterns in multicellular tissues by spatially controlling the aggregation of epithelial spheroids, achieving greater motility than traditional CiliaBots.

This study investigates the impact of AIM2 gene deletion on bone morphology in mice, finding increased cortical thickness and decreased trabecular bone volume and BMD in aged AIM2 null females.

This study shows that inactivating the Mlx network in mice accelerates aging-related phenotypes and increases cancer risk, similar to Myc inactivation, but with different lifespan outcomes.

This study links millisecond conformational dynamics of ubiquitin to protein stability through alanine mutations affecting the C-terminal retracted state.

This paper introduces a method to rapidly and efficiently isolate extracellular vesicles with high purity and recovery, enabling downstream analyses for cancer diagnostics.

This study investigates how P. akamusi tolerates acute hypoxia through multi-omics analysis, revealing metabolic and enzymatic adaptations that support its survival in eutrophic lakes.

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

This study investigates the effects of near-complete Myc inactivation in mice, finding premature aging features but reduced cancer incidence and linking Myc dysregulation to aging and cancer.

This study designs and evaluates indoline-based CD4-mimetic compounds that inhibit HIV-1 more potently and broadly than existing indane-based compounds and sensitize HIV-1 to antibody-dependent cellular cytotoxicity.

This study shows zebrafish embryos are more efficient and robust than larvae for evaluating human norovirus infectivity, enabling virus passaging and UV inactivation testing.

This study shows that kynurenic acid reduces A1 astrocyte activation and promotes A2 astrocyte formation, improving cognitive deficits in HIV-1 gp120 transgenic mice.

This study compares DOPA2 and DSS cross-linkers, finding that faster cross-linking favors the stereospecific complex over encounter complexes in transient protein interactions.

The paper presents a zebrafish embryo-based screen for anti-metastasis drugs using gastrulation as a model, identifying Adrenosterone and Pizotifen as potential candidates.

This study identifies PP2A as a phosphatase that dephosphorylates Parkin and ubiquitin, thereby inhibiting mitophagy.

This paper introduces SPACX, a method to profile protein conformation and interactions in living cells, revealing subcellular-specific heterogeneity and functional differences in PTEN.

This study shows that targeting the minor spliceosome, specifically Rnpc3, reduces tumor burden in multiple cancer models and is associated with poor patient survival in cancer transcriptomes.

This study develops a chemo-mechanical model to explain how immune cell podosomes generate oscillatory growth and coordinated wave dynamics through actin polymerization, myosin contractility, and actin diffusion.

This study shows that nucleobase clustering in RNA with repeat expansions leads to the formation and hollowing of RNA condensates, contributing to neurodegenerative disease mechanisms.

This study shows that autophagy-dependent TOR reactivation via α-ketoglutarate sustains fungal biotrophic growth in host rice cells.

This study identifies SNP markers associated with salt tolerance traits in upland cotton through genome-wide association analysis.

The paper shows that reducing Elys function in a zebrafish model of Kras-driven liver cancer reduces tumour burden by inducing DNA damage and cell death.

This paper investigates how crowder proteins affect the binding affinity and kinetics of the EIN-HPr protein complex using NMR and atomistic modeling, revealing preferential interactions that destabilize the complex.

The paper develops a new alkynyl-enrichable crosslinker for in-vivo crosslinking analysis, identifying 6820 non-redundant crosslinks in human cells with a 1% FDR.

This paper develops a deep-learning enhanced on-chip DSLM system for high-speed volumetric imaging of neural activity in moving Drosophila larvae.

Overexpression of VDAL in Arabidopsis enhances resistance to Verticillium dahliae by preventing degradation of the transcription factor MYB6 through interaction with PUB25/26 E3 ligases.

This study identifies LCK's role in HR repair in ovarian cancer, showing its inhibition sensitizes HR-proficient tumors to PARP inhibitors.

This study compares fucoidan and 2'-Fucosyllactose in inhibiting human norovirus replication in zebrafish larvae, finding only fucoidan effectively inhibits replication.

This study introduces a fast lysine cross-linker DOPA for mass spectrometry analyses, showing it enables rapid protein cross-linking and captures dynamic conformational changes and weak protein-protein interactions.