Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
Y.-T. Yeh, C. Sona, X. Yan, A. Pathak, M. I. McDermott, Z. Xie, L. Liu, A. Arunagiri, Y. Wang, A. Cazenave-Gassiot, A. Ghosh, F. von Meyenn, S. Kumarasamy, S. M. Najjar, S. Jia, , M. N. Poy
The paper shows restoring PITPNA in T2D human islets reverses beta-cell dysfunction by improving insulin granule maturation and glucose-stimulated insulin secretion.
bioRxiv · Jul 6, 2022Cell Biology