A. Abraham

Targeting Metabolic Dependencies in Acute Myeloid Leukemia: A Dual Strategy using Arsenic Trioxide and Artesunate.

This study investigates the combination of artesunate and arsenic trioxide to treat AML with reduced off-target effects on normal hematopoietic stem cells.

Functional traits and phylogeny predict vertical foraging in terrestrial mammals and birds

The paper predicts vertical foraging niches in mammals and birds using functional traits, phylogeny, and predation risk, revealing strong associations with diet, body mass, and geographic patterns.

Using a multiscale lidar approach to determine variation in canopy structure from African forest elephant trails.

The paper uses multiscale lidar data to analyze how forest structure varies on and off elephant trails in Lope National Park, Gabon, finding structural differences linked to elephant activity.

Multiscale modelling of chromatin 4D organization in SARS-CoV-2 infected cells

This study uses polymer physics to model how SARS-CoV-2 infection alters chromatin organization and gene regulation in 4D.

Inhibition of BCR::ABL1 tyrosine kinase activity Aids in the Generation of Stable Chronic Myeloid Leukemia Induced Pluripotent Stem Cells

This study generates stable CML-iPSCs by inhibiting BCR::ABL1 tyrosine kinase activity, enabling disease modeling and drug screening.

Genomic differences and species delimitation: a case for two species in the zoonotic cestode Dipylidium caninum

This study sequenced and compared genomes of Dipylidium caninum isolates from dogs and cats, finding significant genetic differences that suggest two distinct species.

Isolation and genome characterization of Lloviu virus from Italian Schreibers bent-winged bats

The paper isolates and characterizes Lloviu virus from Italian bats, establishing an infectious isolate and conducting evolutionary analysis.

Purified cytosolic crystals from Bacillus thuringiensis as a novel active pharmaceutical ingredient (API)

This paper describes the scalable purification of Bt Cry5B crystals and demonstrates their potent bioactivity against nematodes in vitro and in vivo.

Mosaic patterns of selection in genomic regions associated with diverse human traits

The paper develops a computational framework to analyze selection patterns in genomic regions linked to human traits using GWAS summary statistics and evolutionary measures.

Protection of mice against experimental cryptococcosis by synthesized peptides delivered in glucan particles

The paper shows that glucan particle-based vaccines containing specific peptides from C. neoformans proteins can protect mice against cryptococcosis, with varying efficacy depending on the peptide and mouse strain.

Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans

This paper develops a safe, effective, and scalable anthelmintic based on Bacillus thuringiensis Cry5B for treating human gastrointestinal nematodes.

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

The paper measures nutrient uptake in the tumor microenvironment using PET tracers and finds cancer cells prefer glutamine while myeloid cells consume most glucose.

Evaluating Human Autosomal Loci for Sexually Antagonistic Viability Selection in Two Large Biobanks

The paper evaluates evidence for sexually antagonistic viability selection on autosomal loci in humans using two large biobanks but finds no significant replication of associations, suggesting limited ongoing selection on single locus variation.

Mechanistic macroecology: exploring the drivers of latitudinal variation in terrestrial body size in a General Ecosystem Model

This study uses a mechanistic ecosystem model to evaluate the role of thermoregulation and resource availability in explaining latitudinal body size variation in mammals and birds.

Megafauna decline have reduced pathogen dispersal which may have increased emergent infectious diseases

This study links megafauna extinction to reduced pathogen dispersal, suggesting it may have increased zoonotic disease emergence in humans.

Accounting for diverse evolutionary forces reveals the mosaic nature of selection on genomic regions associated with human preterm birth

The paper develops an approach to analyze evolutionary forces on genomic regions linked to preterm birth and finds diverse signatures like negative and positive selection.

Functional Balance between TCF21-Slug defines phenotypic plasticity and sub-classes in high-grade serous ovarian cancer

The paper identifies TCF21-Slug interactions that define phenotypic plasticity and sub-classes in high-grade serous ovarian cancer.