Treatment history shapes the evolution of complex carbapenem-resistant phenotypes in Klebsiella spp.
T. Lithgow, T. Zhou, M. MCDONALD, N. Rosas, J. Wilksch, J. Barber, J. Li, Y. Wang, Z. Sun, A. Rocker, C. Webb, L. Perlaza-Jimenez, C. Stubenrauch, D. Vijaykrishn, J. Song, , Q. Bao
This study shows that treatment history influences the evolution of carbapenem resistance in Klebsiella by shaping the genetic loci involved and their fitness costs.
bioRxiv · Aug 30, 2022Microbiology