Author

A. Rocker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Bioengineering· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:bacteria (other)· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

M. Diard· 4 shared L. Larsson· 2 shared N. Wenner· 2 shared T. Lithgow· 2 shared W.-D. Hardt· 2 shared A. Aertsen· 1 shared A. Bertola· 1 shared A. Cambre· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersMicrobiology

M. Diard

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Phenotypic heterogeneity drives phage-bacteria coevolution in the intestinal tract

N. Wenner, A. Bertola, L. Larsson, A. Rocker, N. A. Bekele, C. Sauerbeck, L. F. L. Rocha, V. Druelle, A. Harms, M. Diard

This study shows that phenotypic heterogeneity in bacteria affects phage-bacteria coevolution, leading to phage extinction due to genetic resistance evolution in the intestinal tract.

bioRxiv · Nov 8, 2023 · PreprintMicrobiology

Treatment history shapes the evolution of complex carbapenem-resistant phenotypes in Klebsiella spp.

T. Lithgow, T. Zhou, M. MCDONALD, N. Rosas, J. Wilksch, J. Barber, J. Li, Y. Wang, Z. Sun, A. Rocker, C. Webb, L. Perlaza-Jimenez, C. Stubenrauch, D. Vijaykrishn, J. Song, , Q. Bao

This study shows that treatment history influences the evolution of carbapenem resistance in Klebsiella by shaping the genetic loci involved and their fitness costs.

bioRxiv · Aug 30, 2022Microbiology

Vaccine-enhanced competition permits rational bacterial strain replacement in the gut

V. Lentsch, A. Woller, A. Rocker, S. Aslani, C. Moresi, N. Ruoho, L. Larsson, S. A. Fattinger, N. Wenner, E. Cappio Barazzone, W.-D. Hardt, C. Loverdo, M. Diard, E. Slack

The paper demonstrates that oral vaccination combined with engineered competitor strains can exclude pathogens and replace bacterial strains in the mouse gut.

bioRxiv · Jul 20, 2022Microbiology

A Sulfonated Thermoresponsive Injectable Gel for Sequential Release of Therapeutic Proteins to Protect Cardiac Function After a Myocardial Infarction

A. ROCKER, M. Cavasin, N. R. Johnson, R. Shandas, D. Park

bioRxiv · Feb 7, 2022Bioengineering

The component parts of bacteriophage virions accurately defined by a machine-learning approach built on evolutionary features.

T. Y. Thung, M. E. White, W. Dai, J. J. Wilksch, R. S. Bamert, A. Rocker, C. J. Stubenrauch, D. Williams, C. Huang, R. B. Schittelhelm, J. J. Barr, E. Jameson, S. McGowan, Y. Zhang, J. Wang, , T. Lithgow

This paper develops a machine learning tool called STEP3 to accurately define bacteriophage virion components using evolutionary features, validated with mass spectrometry.

mSystems · Jun 29, 2021Peer-reviewedMicrobiology

The expression of virulence increases outer-membrane permeability and sensitivity to envelope stress in Salmonella Typhimurium

M. Sobota, P. N. Rodilla Ramirez, A. Cambre, T. Haas, D. Cornillet, A. Rocker, A. Aertsen, M. Diard

This study shows that upregulating virulence in Salmonella Typhimurium increases membrane permeability and stress sensitivity, revealing a trade-off between virulence and stress resistance.

bioRxiv · Jun 8, 2021 · PreprintMicrobiology

Cooperative virulence can emerge via horizontal gene transfer but is stabilized by transmission

E. Bakkeren, E. Gul, J. S. Huisman, Y. Steiger, A. Rocker, W.-D. Hardt, M. Diard

This study shows that horizontal gene transfer can enable virulence in Salmonella Typhimurium, but cooperative virulence is stabilized by transmission dynamics and population bottlenecks.

bioRxiv · Feb 11, 2021 · PreprintEvolutionary Biology