Author

C. Swale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Y. Coute· 4 shared A. Bougdour· 3 shared M.-a. Hakimi· 3 shared C. Corrao· 2 shared C. MAS· 2 shared D. C. Farhat· 2 shared D. Cannella· 2 shared L. Belmudes· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersMicrobiology

Y. Coute

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

GRA47 and GRA72 are Toxoplasma gondii pore-forming proteins that influence small molecule permeability of the parasitophorous vacuole

M. A. Bitew, P. S. Gaeteb, C. Swale, P. Maru, J. E. Contreras, J. P. J. Saeij

This paper identifies GRA47 and GRA72 as Toxoplasma gondii pore-forming proteins that regulate small molecule permeability of the parasitophorous vacuole, with mutations affecting their function and virulence.

bioRxiv · Nov 15, 2023 · PreprintMicrobiology

Oxidation-sensitive cysteines drive IL-38 amyloid formation

A. Diaz-Barreiro, G. Cereghetti, J. Tonacini, D. Talabot-Ayer, S. Kieffer-Jaquinod, A. Huard, C. Swale, Y. Coute, M. Peter, A. Frances-Monerris, G. Palmer

This study identifies oxidation-sensitive cysteines in IL-38 that drive amyloid formation under oxidative stress, suggesting a new biological role for IL-38 in epithelial barriers.

bioRxiv · Mar 26, 2023Cell Biology

In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming

A. V. Antunes, M. Shahinas, C. Swale, D. C. Farhat, C. Ramakrishnan, C. Bruley, D. Cannella, C. Corrao, Y. Coute, A. B. Hehl, A. Bougdour, I. Coppens, M.-a. Hakimi

This study shows that AP2XII-1 and AP2XI-2 transcription factors reprogram Toxoplasma gondii tachyzoites to merozoites in vitro, enabling the production of pre-sexual stages without using cats.

bioRxiv · Jan 16, 2023 · PreprintMicrobiology

A drug repurposing screen identifies altiratinib as a selective inhibitor of a key regulatory splicing kinase and a potential therapeutic for toxoplasmosis and malaria

C. SWALE, V. BELLINI, M. W. Bowler, F. NARDELLA, M.-P. Brenier-Pinchart, D. Cannella, L. Belmudes, C. MAS, Y. Coute, F. LAURENT, A. Scherf, A. BOUGDOUR, M.-a. HAKIMI

This paper identifies altiratinib as a selective inhibitor of PRP4K/CLK3 kinases in apicomplexan parasites, showing broad-spectrum antiparasitic activity against toxoplasmosis and malaria.

bioRxiv · Nov 3, 2021 · PreprintMicrobiology

A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental genes partitioning in Toxoplasma

D. C. Farhat, M. W. Bowler, G. Communie, D. PONTIER, L. Belmudes, C. MAS, C. Corrao, Y. COUTE, A. BOUGDOUR, T. LAGRANGE, M.-a. HAKIMI, C. Swale

This paper identifies an m6A-dependent polyadenylation mechanism in Toxoplasma gondii that prevents transcriptional read-through and maintains transcriptome integrity, similar to a plant mechanism.

bioRxiv · Feb 23, 2021Microbiology