M. W. Bowler

This paper demonstrates a method to identify multiple binding orientations of small molecule fragments using anomalous signals from sulphur and chlorine atoms, applied to SARS-CoV-2 nsp1 fragments.

The paper determines the structure and activation mechanism of the MKK6-p38α complex using cryo-EM and MD simulations, revealing how phosphorylation and interactions drive MAPK specificity.

This study identifies two ligand-binding sites on SARS-CoV-2 nsp1 using X-ray crystallography and fragment-based screening, offering a foundation for inhibitor development.

This paper identifies altiratinib as a selective inhibitor of PRP4K/CLK3 kinases in apicomplexan parasites, showing broad-spectrum antiparasitic activity against toxoplasmosis and malaria.

This paper identifies an m6A-dependent polyadenylation mechanism in Toxoplasma gondii that prevents transcriptional read-through and maintains transcriptome integrity, similar to a plant mechanism.

The paper identifies potent neutralising antibodies from early COVID-19 patient samples and shows high convergence in antibody sequences across studies.

The paper analyzes data from 56,000 protein crystals processed by MASSIF-1 to evaluate theoretical assumptions about crystal properties and their relationship to diffraction and molecular characteristics.

The paper measures equilibrium relative humidity for common precipitants and shows agreement with Raoult’s law using improved humidity control.