Author

J. P. J. Saeij

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Lourido· 2 shared A. Camejo· 1 shared A. K. Kongsomboonvech· 1 shared A. K. Shalek· 1 shared A. L. Diep· 1 shared A. M. Furuta· 1 shared B. E. Castallanos· 1 shared B. M. Justice· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

S. Lourido

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologybioRxivJan 20, 2020

Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5

A. K. Kongsomboonvech, F. Rodriguez, A. L. Diep…·K. Jensen

This study identifies NLRP3-dependent but inflammasome-independent pathways regulating CD8 T cell IFNγ responses to Toxoplasma gondii vacuolar antigens, independent of ROP5 virulence factors.

DOI 10.1371/journal.ppat.1008327

mousebulk RNA-seq

𝕏 PostBluesky

MicrobiologyCellPeer-reviewedJan 1, 2020

Identification of a master regulator of differentiation in Toxoplasma

B. S. Waldman, D. Schwarz, M. H. Wadsworth…·S. Lourido

This study identifies BFD1 as a master regulator of differentiation in Toxoplasma gondii through genetic screening and single-cell profiling, showing its necessity and sufficiency for the transition from tachyzoites to bradyzoites.

DOI 10.1016/j.cell.2019.12.013

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivPreprintDec 6, 2019

A genome-wide loss-of-function screen identifies Toxoplasma gondii genes that determine fitness in interferon gamma-activated murine macrophages

Y. Wang, L. O. Sangare, T. C. Paredes-Santos…·J. P. J. Saeij

The paper uses a genome-wide CRISPR screen to identify Toxoplasma gondii genes critical for fitness in IFN-gamma-activated murine macrophages, with GRA45 shown to prevent effector aggregation and enhance parasite survival.

DOI 10.1101/867705

mousegenetic perturbation / CRISPR

𝕏 PostBluesky