I. Coppens

XIAP-mediated targeting of endolysosomes to stressed mitochondria occurs in a switch-like, global manner and results in autophagy-independent, sub-organelle level mitochondrial degradation

The paper shows XIAP mediates rapid, global endolysosome targeting to stressed mitochondria, leading to sub-organelle degradation independent of autophagy.

Functional profiling of the Toxoplasma genome during acute mouse infection

The paper uses CRISPR screens to identify 300+ genes in Toxoplasma gondii that affect parasite fitness in mice, revealing new roles in host-parasite interactions and potential drug targets.

In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming

This study shows that AP2XII-1 and AP2XI-2 transcription factors reprogram Toxoplasma gondii tachyzoites to merozoites in vitro, enabling the production of pre-sexual stages without using cats.

Host MOSPD2 enrichment at the parasitophorous vacuole membrane varies between Toxoplasma strains and involves complex interactions

The paper investigates strain-specific variations in host MOSPD2 association with the Toxoplasma parasitophorous vacuole membrane and identifies factors influencing this interaction.

Toxoplasma scavenges mammalian host organelles through usurpation of host ESCRT-III and Vps4

This study shows Toxoplasma uses host ESCRT-III and Vps4 to scavenge host organelles into its parasitophorous vacuole through proteins TgGRA14 and TgGRA64.

Toxoplasma gondii-s basal complex: the other apicomplexan business end is multifunctional

This paper reviews and expands understanding of the basal complex in Toxoplasma gondii, highlighting its multifunctional roles in cell division, import, and motility.

Dense granule protein, GRA64 interacts with host cell ESCRT proteins during Toxoplasma gondii infection

This study identifies GRA64, a Toxoplasma gondii dense granule protein that interacts with host ESCRT proteins, and shows its role in intracystic vesicle formation during chronic infection.

The Rab11-Family Interacting Proteins reveal selective interaction of mammalian recycling endosomes with the Toxoplasma parasitophorous vacuole in a Rab11- and Arf6-dependent manner

The paper identifies Rab11-Family Interacting Proteins (FIPs) that mediate selective interaction of recycling endosomes with the Toxoplasma parasitophorous vacuole, dependent on Rab11 and Arf6.

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts

This study shows that TgATG9 is essential for autophagy and long-term survival of Toxoplasma gondii bradyzoites in tissue cysts.

Chemoprophylaxis vaccination with a Plasmodium liver stage autophagy mutant affords enhanced and long-lasting protection

This paper shows that a Plasmodium liver stage mutant vaccine under chemoprophylaxis regimen provides superior long-lasting protection compared to wild-type sporozoites in mice.

Fussing about fission: defining variety among mainstream and exotic apicomplexan cell division modes

This paper defines and classifies different cell division modes in Apicomplexa parasites, highlighting variations in budding site, offspring number, and karyokinesis timing across species and life stages.

Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response

The paper shows mitochondria form contact sites with the nucleus to facilitate a pro-survival retrograde response by stabilizing transcription factors like NF-kB.

Toxoplasma FER1 is a versatile and dynamic mediator of differential microneme trafficking and microneme exocytosis

This study identifies FER1 as a key mediator of microneme trafficking and exocytosis in Toxoplasma gondii, showing its dynamic role in organelle transport and secretion.

A role for Toxoplasma gondii chloroquine resistance transporter in bradyzoite viability and digestive vacuole maintenance

This study shows that the Toxoplasma gondii chloroquine resistance transporter (TgCRT) is essential for maintaining the digestive vacuole and bradyzoite viability, suggesting it as a potential target for treating chronic Toxoplasma infection.

A member of the ferlin calcium sensor family is essential for Toxoplasma gondii rhoptry secretion

This study identifies TgFER2, a Ca2+ sensor essential for rhoptry secretion in Toxoplasma gondii, which is required for host cell invasion.

Listeria monocytogenes virulence factors are secreted in biologically active Extracellular Vesicles

This study shows Listeria monocytogenes secretes biologically active extracellular vesicles containing virulence factors like LLO and PI-PLC, which contribute to cytotoxicity in macrophages.