H. Jin

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

Conditional c-MYC activation in catecholaminergic cells drives distinct neuroendocrine tumors: neuroblastoma vs somatostatinoma

This study creates two mouse models with conditional c-MYC activation in specific cell types, leading to distinct neuroendocrine tumors resembling human neuroblastoma and somatostatinoma.

Discovery of Phenyl-β-D-glucuronide Medical Function for in Vivo Producing Handheld Gas Sensor Detectable Phenol-like Breath Marker: The Future of Induced Volatolomics in Cancer Risk Pre-warning

The paper introduces phenyl-β-D-glucuronide as a bio-compatible agent for induced volatolomics, enabling non-invasive cancer risk detection via a handheld breath sensor with high accuracy.

Conserved Pseudouridines in Helix 69 of the Ribosome are Important for Ribosome Dynamics in Translation

This study shows that conserved pseudouridines in ribosome helix 69 affect ribosome dynamics and translation efficiency, particularly for rare codons.

Disease resistance of Brassica juncea to Sclerotinia sclerotiorum is established through the induction of indole glucosinolate biosynthesis

The paper identifies a resistant Brassica juncea line H83 and reveals a novel regulatory network involving indole glucosinolate biosynthesis in response to Sclerotinia sclerotiorum infection.

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

This paper creates a spatial cell atlas of neuroblastoma, revealing tumor heterogeneity through multi-omics data and identifying spatial compartmentalization and signaling patterns.

Mass spectrometry imaging links interxylary cork formation with phytochemical distribution in Scutellaria baicalensis

This study uses mass spectrometry imaging to show that interxylary cork formation in Scutellaria baicalensis correlates with spatial phytochemical distribution, revealing distinct flavonoid accumulation patterns in different root tissue decay stages.

Discovery of a Novel Chemotype as DYRK1A Inhibitors against Alzheimer's disease: Computational Modeling and Biological Evaluation

This paper identifies a novel DYRK1A inhibitor, compound Q17, through computational screening and validates its efficacy in reducing AD-related pathology in vitro and in vivo.

CSTA: A Biomarker Regulating Esophageal Stricture Epithelial Barrier, Potential Medication Target

The paper identifies CSTA as a biomarker for esophageal epithelial barrier function and shows FK506 can rescue CSTA-knockdown effects in strictures.

Multimodal single-cell profiling of T cell specificity and reactivity in lung cancer

This study uses multimodal single-cell profiling to analyze T cell specificity and reactivity in lung cancer patients, identifying tumor- and virus-reactive T cells and their functional states.

β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of femoral head

This study shows that β-catenin inhibition disrupts osteogenic/adipogenic differentiation in bone marrow mesenchymal cells, contributing to glucocorticoid-induced osteonecrosis of the femoral head.

Two functionally distinct HEATR5 protein complexes are defined by fast-evolving co-factors in yeast

The paper identifies two distinct HEATR5 protein complexes in yeast, defined by fast-evolving co-factors Laa2 and Lft1, and shows they function in intra-Golgi recycling with different roles in AP1 localization.

Collagenesis Orchestrates Mechanoadaptive Homeostasis of Intervertebral Disc

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

This study shows JMJD6 links pre-mRNA splicing and metabolism in MYC-driven cancers, and its inhibition enhances therapeutic response to splicing inhibitors.

Fungal small RNAs ride in extracellular vesicles to enter plant cells through clathrin-mediated endocytosis

This study shows fungal small RNAs are secreted via extracellular vesicles and enter plant cells through clathrin-mediated endocytosis, using BcPLS1 as an EV biomarker.

An intrinsically Disordered RNA Binding Protein Modulates mRNA Translation and Storage

This study investigates how an intrinsically disordered RNA-binding protein modulates mRNA translation and storage through distinct mechanisms involving ribosome movement and post-translational modifications.

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

This study shows that inhibiting PP2A and WEE1 together can kill colon cancer cells by causing DNA replication collapse and cell death, and that resistance to this treatment suppresses tumor growth.

Heat dissipation from photosynthesis contributes to maize thermoregulation under suboptimal temperature conditions

This study investigates how maize thermoregulates by dissipating heat from photosynthesis, showing that non-photochemical quenching (NPQ) helps maintain optimal leaf temperatures under suboptimal conditions.

Artificial nanovesicles for dsRNA delivery in spray induced gene silencing for crop protection

This paper develops artificial nanovesicles to deliver dsRNA for spray-induced gene silencing, enhancing stability and extending protection against Botrytis cinerea in crops.

Botrytis cinerea small RNAs are associated with tomato AGO1 and silence tomato defense-related target genes supporting cross-kingdom RNAi

The paper reanalyzes existing data to show cross-kingdom RNAi between Botrytis cinerea and tomato, contradicting a previous study.

Utilization of an Artery-on-a-chip to unravel novel regulators and therapeutic targets in vascular diseases

The paper develops an artery-on-a-chip model to study shear stress effects on vascular diseases and identifies novel therapeutic targets.

Depletion of collagen IX alpha2 interferes osteochondral homeostasis of the knee joint which ultimately causing osteoarthritis-like articular cartilage damage

This study shows that Col92 deficiency in mice leads to osteochondral homeostasis disruption and osteoarthritis-like cartilage damage in the knee joint.

A dynamic template complex mediates Munc18-chaperoned SNARE assembly

The paper investigates the dynamics and function of Munc18-mediated SNARE template complexes using optical tweezers, revealing a dynamic conformational transition that facilitates specific SNAP-25 binding.

Monoallelically-expressed Noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression

The paper identifies SNULs, noncoding RNAs that form nucleolar territories on NOR chromosomes and regulate rRNA expression by influencing pre-rRNA sorting and processing.

Time-varying Dynamic Network Model For Dynamic Resting State Functional Connectivity in fMRI and MEG imaging

This paper introduces a time-varying dynamic network model to analyze dynamic resting state functional connectivity in fMRI and MEG data, showing improved performance in capturing brain dynamics and detecting state transitions.

Variation in morpho-physiological and metabolic responses to low nitrogen stress across the sorghum association panel

The paper quantifies variation in sorghum's morphological, physiological, and metabolic responses to nitrogen stress and links these to grain yield under different conditions.

Efficacy of Parainfluenza Virus 5 (PIV5)-vectored Intranasal COVID-19 Vaccine as a Single Dose Vaccine and as a Booster against SARS-CoV-2 Variants

This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.

Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells

This study modifies MR1 ligands to assess their impact on MR1-restricted T cell activation, revealing variable IFN-gamma responses and structural dynamics influencing recognition.

Association Mapping Across a Multitude of Traits Collected in Diverse Environments Identifies Pleiotropic Loci in Maize.

This study identifies pleiotropic loci in maize by analyzing trait associations across diverse environments using high-density genetic markers and resampling-based genome-wide association tests.

Sorghum Association Panel Whole-Genome Sequencing Establishes Pivotal Resource for Dissecting Genomic Diversity

The paper reports whole-genome sequencing of 400 sorghum accessions, identifying novel genomic associations and improving predictive models for plant traits.