Membrane-type 1 matrix metalloproteinase (MMP-14) modulates tissue homeostasis by a non-proteolytic mechanism
M. G. Attur, C. Lu, X. Zhang, T. Han, C. Alexandre, C. Valacca, S. Zheng, S. Meikle, B. Brukner Dabovic, E. Tassone, Q. Yang, V. Kolupaeva, S. Yakar, S. B. Abramson, P. Mignatti
This study shows that MT1-MMP regulates tissue homeostasis via a non-proteolytic mechanism by controlling skeletal stem cell differentiation, independent of its proteolytic activity.
bioRxiv · Sep 1, 2020Cell Biology