T. Han

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

Noninvasive cancer detection by extracting and integrating multi-modal data from whole-methylome sequencing of plasma cell-free DNA

This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.

Full-length transcriptome maps of reef-building coral illuminate the molecular basis of calcification, symbiosis, and circadian genes

The paper sequenced full-length transcriptomes of four reef-building corals to uncover molecular mechanisms of calcification, symbiosis, and circadian genes.

An intergeneric recombinant geminivirus causes soybean stay-green disease

This paper identifies a novel intergeneric recombinant geminivirus as the cause of soybean stay-green disease, showing it induces symptoms and can be detected in seed coats but not seeds.

Genome edited colorectal cancer organoid models reveal distinct microRNA activity patterns across different mutation profiles

The paper uses genome-edited colorectal cancer organoids to identify microRNA expression patterns linked to specific mutation profiles and shows miR-24-3p's role in promoting cancer cell survival.

Transcriptomics analysis reveals intracellular mutual regulation of coral-zooxanthella holobionts

The paper analyzes transcriptomes and small RNAs of corals and their symbionts to reveal mutual gene regulation mechanisms and miRNA roles in host-symbiont interactions.

Explicit expression of mesophyll conductance in the traditional leaf photosynthesis-transpiration coupled model and its physiological significances

This study develops a photosynthesis-transpiration coupled model that explicitly incorporates mesophyll conductance, improving predictions of leaf gas exchange by optimizing parameterization methods.

The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-kB activation

This study identifies UBE4B as a host factor that ubiquitinates HTLV-1 Tax to promote NF-κB activation and cell survival in ATLL.

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilities

This study identifies four subtypes of castration-resistant prostate cancer using ATAC-seq and RNA-seq data, revealing novel therapeutic targets and classification for 370 patients.

Membrane-type 1 matrix metalloproteinase (MMP-14) modulates tissue homeostasis by a non-proteolytic mechanism

This study shows that MT1-MMP regulates tissue homeostasis via a non-proteolytic mechanism by controlling skeletal stem cell differentiation, independent of its proteolytic activity.

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger Cyclin K degradation

This paper discovers a molecular glue, HQ461, that promotes CDK12-DDB1 interaction, leading to Cyclin K degradation and cell death.

Lineage reversion drives WNT independence in intestinal cancer

This study identifies lineage reversion as a mechanism enabling WNT-independent growth in intestinal cancer by integrating genetic alterations and extracellular signals.

Genome-wide CRISPR screens identify essential cell growth mediators in BRAF-inhibitor resistant melanoma

The paper identifies key regulators of BRAF inhibitor resistance in melanoma using CRISPR screens and integrates multi-omics data to reveal CDK6-dependent mechanisms.

An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants

The paper creates KRAS mutant mouse models to study how different oncogenic variants affect tumor development and therapy response in vivo.

RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia

This study shows RNA nucleates phase separation of glycolysis enzymes into G bodies in yeast under hypoxia, revealing their biophysical properties and structural integrity.

Function and clinical relevance of RHAMM isoforms in pancreatic tumor progression

This study identifies RHAMMB as a key driver of pancreatic tumor metastasis, showing its upregulation in PNETs and correlation with poor patient survival through EGFR signaling.