Author

C. Vela-Rodriguez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1

Frequent Co-Authors

L. Lehtiö· 4 shared Y. Ashok· 3 shared B. M. Paschal· 2 shared C. Yang· 2 shared H. I. Alanen· 2 shared A. Wagner· 1 shared D. Mennerich· 1 shared F. Liu· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersBiochemistry

L. Lehtiö

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4 papers

Recent·Most cited

BiochemistrybioRxivPreprintNov 29, 2023

Oligomerisation mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor

C. Vela-Rodriguez, C. Yang, H. I. Alanen…·L. Lehtiö

This study identifies the D2 domain of DTX3L as critical for forming oligomeric complexes that enable the DTX3L-PARP9 complex to read mono-ADP-ribosylated androgen receptor.

DOI 10.1101/2023.11.29.569193

experimental assayprotein folding & dynamics

BiochemistrybioRxivMar 13, 2023

Discovery of DTX3L inhibitors through a homogeneous FRET-based assay that monitors formation and removal of poly-ubiquitin chains

C. Vela-Rodriguez, I. Scarpulla, Y. Ashok, L. Lehtiö

This paper develops a FRET-based assay to monitor DTX3L auto-ubiquitination and identifies low micromolar inhibitors, while also expanding the system to study deubiquitinases.

DOI 10.1016/j.slasd.2023.08.005

experimental assaydrug response / drug discovery

BiochemistrybioRxivJan 30, 2023

The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA double strand repair through mutual regulation of their protein levels

D. Mennerich, Y. Ashok, C. Vela-Rodriguez…·T. Kietzmann

This paper identifies a regulatory feedback loop between DTX3L and USP28 that modulates DNA double-strand break repair by controlling protein levels and repair pathway efficiency.

DOI 10.1016/j.isci.2025.112990

experimental assaywet-lab / biochemical assay

BiochemistrybioRxivPreprintJun 14, 2021

Reconstitution of the DTX3L-PARP9 complex reveals determinants for high affinity heterodimer formation and enzymatic function

Y. Ashok, C. Vela-Rodriguez, C. Yang…·L. Lehtiö

This study reconstitutes the DTX3L-PARP9 complex to identify determinants for high-affinity heterodimer formation and enzymatic function.

DOI 10.1101/2021.06.14.448324

protein structureexperimental assay