The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis
M. A. A. Sikder, R. B. Rashid, T. Ahmed, I. Sebina, D. R. Howard, M. A. Ullah, M. M. Rahman, J. P. Lynch, B. Curren, R. B. Werder, J. Simpson, A. Bissell, M. Morrison, C. Walpole, K. J. Radford, , S. Phipps
The paper shows that a maternal low-fibre diet disrupts infant immune development, increasing susceptibility to respiratory infections and asthma, and that propionate-producing bacteria can reverse this effect.
bioRxiv · Jan 5, 2023Immunology