Author

C. C. Nelson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Assay:bulk RNA-seq· 4 Research Focus:cancer & tumor microenvironment· 4 Research Focus:metabolism & bioenergetics· 3 Assay:metabolomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

A. Rockstroh· 3 shared J. H. Gunter· 3 shared K. D. Tousignant· 3 shared M. C. Sadowski· 3 shared S. J. Blanksby· 3 shared A. C. Herington· 2 shared A. P. Bowman· 2 shared B. L. J. Poad· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

A. Rockstroh

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Author profile →

7 papers

Recent·Most cited

Valine Catabolism Drives Bioenergetic and Lipogenic Fuel Plasticity in Prostate Cancer

C. L. Bidgood, L. K. Philp, A. Rockstroh, M. Lehman, C. C. Nelson, M. C. Sadowski, J. H. Gunter

This study identifies valine catabolism as a key driver of bioenergetic and lipogenic flexibility in prostate cancer, with potential therapeutic implications.

bioRxiv · Jan 1, 2024 · PreprintCancer Biology

Gene expression based inference of drug resistance in cancer

S. Chawla, A. Rockstroh, M. Lehman, E. Rather, A. Jain, A. Anand, A. Gupta, N. Bhattacharya, S. Poonia, P. Rai, N. Das, A. Majumdar, J. Jayadeva, G. Ahuja, B. G. Hollier, , D. Sengupta

This study uses gene expression data and machine learning to predict drug resistance in cancer by analyzing pathway activity patterns rather than gene expression levels alone.

bioRxiv · Nov 17, 2021Cancer Biology

Isomeric lipid signatures reveal compartmentalised fatty acid metabolism in cancer

R. S. E. Young, A. P. Bowman, K. D. Tousignant, B. L. J. Poad, J. H. Gunter, L. K. Philp, C. C. Nelson, S. Ellis, R. M. A. Heeren, M. C. Sadowski, S. J. Blanksby

This study uses stable-isotope labelled fatty acids to reveal distinct metabolic fates of exogenous and de novo synthesized fatty acids in cancer cells, showing compartmentalized lipid metabolism.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology

Metabolic plasticity in cancer activates apocryphal pathways for lipid desaturation

R. S. E. Young, A. P. Bowman, E. D. Williams, K. D. Tousignant, C. L. Bidgood, V. R. Narreddula, R. Gupta, D. L. Marshall, B. L. Poad, C. C. Nelson, S. R. Ellis, R. M. Heeren, M. Sadowski, S. J. Blanksby

The paper reveals metabolic plasticity in cancer through isomer-resolved lipidomics, identifying apocryphal pathways for lipid desaturation and their impact on lipid structure and function.

bioRxiv · Jun 7, 2020 · PreprintBiochemistry

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

K. D. Tousignant, A. Rockstroh, B. L. J. Poad, A. Talebi, R. R. S. Young, A. T. Fard, R. Gupta, T. Zang, C. Wang, M. L. Lehman, J. V. Swinnen, S. J. Blanksby, C. C. Nelson, M. C. Sadowski

This study identifies therapy-induced lipid uptake and remodeling as drivers of ferroptosis hypersensitivity in prostate cancer, offering new strategies to combat drug resistance.

bioRxiv · Jan 8, 2020Cancer Biology

The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype

P. B. Thomas, P. L. Jeffery, M. D. Gahete, E. J. Whiteside, C. Walpole, M. L. Maugham, L. Jovanovic, J. H. Gunter, E. D. Williams, C. C. Nelson, A. C. Herington, R. M. Luque, R. N. Veedu, L. K. Chopin, I. Seim

This study identifies GHSROS, a lncRNA upregulated in prostate cancer, which promotes aggressive tumor traits and may be a therapeutic target.

bioRxiv · Jun 26, 2019Cancer Biology

No effect of administration of unacylated ghrelin on subcutaneous PC3 xenograft growth in a Rag1-/- mouse model of metabolic dysfunction

M. L. Maugham, L. K. Chopin, I. Seim, P. B. Thomas, G. J. Crisp, E. T. Shah, A. C. Herington, K. A. Brown, L. S. Gregory, C. C. Nelson, P. L. Jeffery

This study investigates the effect of unacylated ghrelin on PC3 xenograft growth in Rag1-/- mice with metabolic dysfunction, finding no effect on tumor growth but improved glucose tolerance.

bioRxiv · May 22, 2018Cancer Biology