M. Morrison

Toxicogenomic analysis of the carcinogenic potential of plastic additives

This study analyzes the carcinogenic potential of 2,712 plastic additives using toxicogenomic methods, finding over 150 known carcinogens and most lacking carcinogenicity data.

Spatiotemporal Dynamics of Vcam1 Regulates Cholangiocarcinoma Mass Expansion and Tumor Dissemination under Growth-suppressive Peritumoral Myofibroblasts

This study shows that Vcam1 expression in cholangiocarcinoma cells is regulated by peritumoral myofibroblasts, promoting tumor dissemination while suppressing growth.

The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis

The paper shows that a maternal low-fibre diet disrupts infant immune development, increasing susceptibility to respiratory infections and asthma, and that propionate-producing bacteria can reverse this effect.

How many ecological niches are defined by the superabundant marine microbe Prochlorococcus?

The paper introduces a tree-free likelihood method to identify ecotypes in Prochlorococcus and finds 24 ecotypes in 96 genomes, more than the commonly recognized five.

Paradoxical Roles of Peritumoral Myofibroblasts in Intrahepatic Cholangiocarcinoma Growth and Metastasis

This study shows peritumoral myofibroblasts suppress iCCA growth but promote metastasis through Vcam1-dependent mechanisms.

Insights into the catalytic properties of the mitochondrial rhomboid protease PARL

This study investigates the catalytic properties of the mitochondrial rhomboid protease PARL using in vitro assays, revealing substrate preferences and activity enhancements under specific conditions.

First-principles prediction of the information processing capacity of a simple genetic circuit

The paper predicts the information processing capacity of a genetic circuit using a minimal model based on published data and compares it with experimental results in E. coli.

Secreted microbial metabolites modulate gut immunity and inflammatory tone

The paper identifies gut bacteria that suppress NF-κB activity and inflammatory responses, suggesting microbiome modulation as a potential therapeutic strategy for IBD.

Theoretical investigation of a genetic switch for metabolic adaptation

The paper models a genetic switch in E. coli that uses membrane transport and enzymatic degradation to control metabolic enzyme production based on metabolite availability.

Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy and the host’s genotype upon microbiome composition

The paper uses shotgun metagenomics to analyze the gut microbiome in AS patients, finding enriched bacterial epitopes linked to HLA-B27 and effects of TNFi therapy and host genotype on microbiome composition.

Enterococcus faecalis AHG0090 is a genetically tractable bacterium and produces a secreted peptidic bioactive that suppresses NF-kB activation in human gut epithelial cells

The paper isolates and characterizes E. faecalis AHG0090, showing it suppresses NF-κB activation in human gut cells and produces a heat- and protease-resistant peptidic bioactive.