Transcriptional and clonal characterization of cytotoxic CD8+ T cells in crescentic glomerulonephritis
Y. Zhao, A. Mueller, H. Cicek, H.-J. Paust, A. Sivayoganathan, A. Linke, C. Wegscheid, T. Wiech, T. B. Huber, C. Meyer-Schwesinger, S. Bonn, U. P. Panzer, G. Tiegs, C. F. Krebs, K. Neumann
This study identifies clonally expanded cytotoxic CD8+ T cells in ANCA-associated cGN and shows their pathogenic role in kidney disease progression.
bioRxiv · Aug 31, 2022Immunology