T. B. Huber

This study determines the structure of the N-terminal didomain d1_d2 of THSD7A, revealing a non-canonical thrombospondin repeat fold with unique structural features contributing to its antigenicity.

This study identifies Tr1 cells in glomerulonephritis, showing their suppressive function and potential as therapeutic targets.

This study identifies clonally expanded cytotoxic CD8+ T cells in ANCA-associated cGN and shows their pathogenic role in kidney disease progression.

The paper identifies GM-CSF-producing T cells that drive glomerulonephritis by licensing monocyte-derived cells to produce MMP12, leading to renal tissue damage.

This study shows that loss of DNA repair gene Ercc1 in podocytes leads to DNA damage, proteinuria, and kidney disease, linked to mTORC1 activation and aging.

The paper develops a deep learning method for analyzing kidney biopsy images to quantify podocyte loss, identifying morphometric signatures in ANCA-GN patients for risk stratification.

This paper introduces a method to isolate and analyze glomerular cell types from reporter-free mice, revealing proteome differences and cell communication networks.