P. Velica

The paper shows that low oxygen levels during T cell activation enhance antitumour cytotoxicity, even when subsequent culture is under high oxygen.

This study shows that glutarate regulates T cell function and metabolism by inhibiting KGDDs and modifying the pyruvate dehydrogenase E2 subunit, enhancing CD8+ T cell cytotoxicity and reducing tumor growth.

This study shows lactate can displace glucose as a carbon source for activated CD8+ T cells and alters their transcriptome, affecting effector differentiation markers.

This study shows that modifying HIF-2α expression in CD8+ T cells enhances their anti-tumor activity through improved cytotoxic function and resistance to hypoxia.

This study shows that lactate enhances the anti-tumour activity of cytotoxic T cells by increasing their proliferation and cytotoxicity during exercise.