Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
P. P. Cunha, E. Minogue, L. C. Krause, R. M. Hess, D. Bargiela, B. J. Wadsworth, L. Barbieri, C. Brombach, I. P. Foskolou, I. Bogeski, P. Velica, R. Johnson
The paper shows that low oxygen levels during T cell activation enhance antitumour cytotoxicity, even when subsequent culture is under high oxygen.
bioRxiv · Nov 25, 2022Immunology
E. A. Minogue, P. P. Cunha, A. Quaranta, J. Zurita, S. K. Sah-Teli, B. Wadsworth, R. Hughes, G. Grice, P. Velica, D. Bargiela, L. Barbieri, C. Wheelock, J. A. Nathan, P. Karppinen, I. P. Foskolou, R. S. Johnson
This study shows that glutarate regulates T cell function and metabolism by inhibiting KGDDs and modifying the pyruvate dehydrogenase E2 subunit, enhancing CD8+ T cell cytotoxicity and reducing tumor growth.
bioRxiv · Oct 20, 2022 · PreprintImmunology
I. P. Foskolou, P. P. Cunha, E. Minogue, B. Nicolet, A. Guislain, C. Jorgensen, N. D. Zandhuis, L. Barbieri, D. Bargiela, D. Nathanael, P. Tyrakis, A. Palazon, M. Wolkers, R. S. Johnson
This study shows S-2HG and R-2HG differentially regulate CD8+ T cell function, with S-2HG enhancing anti-tumour activity and T cell fitness.
bioRxiv · Aug 18, 2022Immunology
L. Barbieri, P. Velica, P. A. Gameiro, P. P. Cunha, I. P. Foskolou, D. Bargiela, H. Rundqvist, R. Johnson
This study shows lactate can displace glucose as a carbon source for activated CD8+ T cells and alters their transcriptome, affecting effector differentiation markers.
bioRxiv · Dec 14, 2021 · PreprintImmunology
H. Rundqvist, P. Velica, L. Barbieri, P. Gameiro, P. Cunha, M. Gojkovic, S. Mijwel, E. Ahlstedt, I. P. Foskolou, M. Ruiz-Perez, M. Arsenian-Henriksson, J. Ule, A. Ostman, R. Johnson
This study shows that lactate enhances the anti-tumour activity of cytotoxic T cells by increasing their proliferation and cytotoxicity during exercise.
bioRxiv · Mar 9, 2019 · PreprintImmunology