C. Strain-Damerell

Architecture and regulation of filamentous humancystathionine beta-synthase

This study uses cryo-electron microscopy to reveal how human CBS regulates activity through conformational changes in its regulatory domain.

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor.

The paper introduces a computational pipeline to design irreversible inhibitors, identifying a potent SARS-CoV-2 Mpro inhibitor with low micromolar IC50.

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

The paper identifies fragment hits against SARS-CoV-2 main protease using crystallography and mass spectrometry, revealing structural insights for drug design.

Strategies to improve scFvs as crystallization chaperones suggested by analysis of a complex with the human PHD-bromodomain SP140

The paper uses a scFv to solve the structure of SP140's PHD-bromodomain and suggests strategies to improve scFvs as crystallization chaperones.

Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism

The paper determines the cryo-EM structure of the FXN-bound active human ISC biosynthesis complex, revealing how FXN activates NFS1 by removing zinc inhibition and stabilizing protein interfaces.