Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy
T. Tezil, M. Chamoli, C.-P. Ng, R. P. Simon, V. J. Butler, M. Jung, J. Andersen, A. W. Kao, E. Verdin
This study identifies p300 as a target of NDGA, showing it inhibits p300 acetyltransferase activity and activates autophagy, contributing to lifespan extension.
bioRxiv · Jul 30, 2019Cell Biology