M. Jung

Benchmarking remote sensing methods to capture plant functional diversity from space

This study benchmarks remote sensing methods to estimate plant functional diversity using synthetic data from BOSSE, identifying optimal metrics, variables, and validation strategies.

Integrative multi-environmental genomic prediction in apple

This study applies statistical and deep learning models to multi-environmental genomic prediction in apple, showing improved predictive ability for certain traits.

Characterization of Tgl2, a putative lipase in yeast mitochondria

This study characterizes Tgl2, a putative TAG lipase in yeast mitochondria, showing its dimerization, catalytic residues, and role in mitochondrial lipid homeostasis.

Sbh1/Sec61beta is a specific signal peptide receptor within the Sec61 channel

This study identifies Sbh1/Sec61β as a specific signal peptide receptor that recognizes and guides substrates into the Sec61 channel through its cytosolic IDR and conserved regions.

Inhibition of the macrophage demethylase LSD1 reverses Leishmania amazonensis-induced transcriptomic changes and causes a decrease in parasite load

This study shows that inhibiting LSD1 in macrophages reduces Leishmania parasite load and reverses infection-induced transcriptomic changes.

The genetic basis of apple shape and size unraveled by digital phenotyping

This study identifies SNPs associated with apple fruit shape, size, and skin color using digital phenotyping and genome-wide association analysis.

A novel PEX14/PEX5 interface links peroxisomal protein import and receptor recycling

This paper identifies a novel PEX14/PEX5 interface involved in peroxisomal protein import and receptor recycling through biochemical and structural analysis.

Structure of recombinant formate dehydrogenase from Methylobacterium extorquens (MeFDH1)

The paper determines the structure of recombinant formate dehydrogenase from Methylobacterium extorquens using cryo-electron microscopy, revealing a noncanonical active site and dynamic structural features.

Modelling the probability of meeting IUCN Red List criteria to support reassessments.

This paper develops models to predict the probability of species meeting specific IUCN Red List criteria, improving extinction risk assessments by identifying key predictors for each criterion.

Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

This study shows that E-cadherin upregulates the serine synthesis pathway in breast cancer cells, supporting proliferation and metastasis by providing metabolic precursors and resistance to oxidative stress.

The Mechanical Influence of Densification on Initial Epithelial Architecture

The paper investigates how cell density and mechanical constraints influence epithelial architecture transitions, showing that crowding drives the first transition and adhesion drives the second.

Clinorotation inhibits myotube formation by fluid motion, not by simulated microgravity

This study shows that clinorotation inhibits myotube formation due to fluid motion, not simulated microgravity, and recommends control experiments to distinguish these effects.

A 3D bioprintable hydrogel with tuneable stiffness for exploring cells encapsulated in matrices of differing stiffnesses

This study develops a tunable 3D bioprintable hydrogel to investigate how matrix stiffness and biological motifs affect cell behavior.

A comprehensive single cell data analysis of in lymphoblastoid cells reveals the role of Super-enhancers in maintaining EBV latency

This study uses scRNA-seq to analyze EBV latency in lymphoblastoid cells, identifying two distinct clusters with different EBV gene expression and revealing the role of super-enhancers in maintaining latency.

The global exposure of species ranges and protected areas to forest management

This study shows that forest management practices affect species ranges and protected areas, potentially increasing extinction risks.

Proteomics identifies substrates and a novel component in hSnd2-dependent ER protein targeting

The paper identifies substrates and a novel component, hSnd3, in the hSnd2-dependent ER protein targeting pathway through proteomic analysis.

Predictability and transferability of local biodiversity environment relationships

This study evaluates the predictability and transferability of local biodiversity measures using environmental heterogeneity data from remote sensing.

Dissecting the interactions of PINK1 with the TOM complex in depolarized mitochondria

This study investigates how PINK1 interacts with the TOM complex in depolarized mitochondria, revealing the role of TOM70 and TOM40 in its association with the mitochondrial outer membrane.

A high-throughput 3D bioprinted cancer cell migration and invasion model with versatile and broad biological applicability

This paper develops a high-throughput 3D bioprinted model for studying cancer cell migration and invasion, enabling real-time analysis and drug screening.

A unified model for the biogenesis of mitochondrial outer membrane multi-span proteins

This study investigates the biogenesis of mitochondrial outer membrane multi-span proteins using yeast and Om14, showing that both protein factors and membrane properties influence their integration.

In vitro validation of neoantigen prediction algorithm for developing personalized cancer vaccine therapy

The paper validates a neoantigen prediction algorithm, Neopepsee, by testing its immunogenicity using ELISpot assays on patient-derived samples and compares it to pVACseq.

In vivo mitochondrial matrix proteome profiling reveals RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase

The paper uses a transgenic mouse model to profile mitochondrial matrix proteomes and identifies RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase involved in CoQ biosynthesis and mitochondrial function.

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas

This paper shows that FA pathway deficiency in squamous cell carcinomas leads to high structural variant rates and copy number alterations, linking genomic instability to tumor progression.

Endomembrane systems are reorganized by ORF3a and Membrane (M) of SARS-CoV-2

This study identifies ORF3a and M proteins of SARS-CoV-2 as reorganizing the endoplasmic reticulum and mitochondrial-associated membrane, with potential therapeutic implications.

Transcriptional silencing of ALDH2 in acute myeloid leukemia confers a dependency on Fanconi anemia proteins

This study identifies ALDH2 transcriptional silencing in AML as a dependency on FA proteins, suggesting FA pathway targeting as a therapeutic strategy.

Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility

The paper shows PEX14 binds microtubules and competes with kinesin for binding sites, linking peroxisome motility and protein import.

Active fatty acid oxidation defines the cellular response towards reactive oxygen species

The paper investigates how reactive oxygen species (ROS) affect cell differentiation and identifies fatty acid oxidation as a protective mechanism in neutrophils and other cell types.

Genome-Enabled Discovery of Anthraquinone Biosynthesis in Senna tora

The paper identifies a CHS-L gene responsible for anthraquinone biosynthesis in S. tora using genomics, transcriptomics, metabolomics, and biochemistry.

Areas of global importance for terrestrial biodiversity, carbon, and water

The paper identifies global terrestrial areas prioritized for conservation to maximize synergies between biodiversity, carbon retention, and water provisioning.

Kappa but not delta or mu opioid receptors form homodimers at low membrane densities

The paper investigates opioid receptor dimerization at different membrane densities and finds that kappa receptors form dimers at physiological densities while delta and mu remain monomeric.